{"id":"W4407698792","doi":"10.1200/jco.2025.43.5_suppl.147","title":"Deep prostate-specific antigen (PSA) decline among early participants (pts) in LIBERTAS, a phase 3 study of apalutamide (APA) plus continuous versus intermittent androgen deprivation therapy (ADT) in metastatic castration-sensitive prostate cancer (mCSPC).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Biotech","keywords":"Medicine; Androgen deprivation therapy; Prostate cancer; Prostate-specific antigen; Internal medicine; Prostate; Castration; Oncology; Urology; Hormone; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001411173,0.0006736311,0.0008089403,0.0002310771,0.0002706564,0.0005869861,0.0006910543,0.0005406541,0.003526455],"category_scores_gemma":[0.0009084243,0.0003383934,0.0008229053,0.0002681048,0.0006154821,0.0004735195,0.0005975902,0.002009597,0.0004449778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007674829,"about_ca_system_score_gemma":0.001609556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001605353,"about_ca_topic_score_gemma":0.004010349,"domain_scores_codex":[0.9996791,0.0001291977,0.0000198091,0.00005833555,0.00003845444,0.00007516309],"domain_scores_gemma":[0.9993685,0.00009033484,0.0001692863,0.00003207616,0.00004219192,0.0002977071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7083566,0.05055972,0.06104476,0.0009288664,0.001335909,0.0003182431,0.0009353556,0.001192085,0.03210958,0.0002663383,0.003302879,0.1396497],"study_design_scores_gemma":[0.2966675,0.5923793,0.1004227,0.00007658022,0.001183766,0.0003440855,0.0002929401,0.0008854112,0.003544968,0.0001257362,0.00403913,0.00003783494],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967926,0.0005521515,0.0001952816,0.0002201288,0.00003287838,0.0008905292,0.0005074772,0.00001904121,0.0007898704],"genre_scores_gemma":[0.9933956,0.0006074731,0.001281039,0.0004336421,0.00005788614,0.001691032,0.0009642934,0.000008310374,0.001560829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003526455,"threshold_uncertainty_score":0.01179713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1759869625840245,"score_gpt":0.4984948703754902,"score_spread":0.3225079077914658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}