{"id":"W4407699835","doi":"10.1200/jco.2025.43.5_suppl.219","title":"Efficacy of olaparib (ola) plus abiraterone (abi) versus placebo (pbo) plus abi in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) with a germline or somatic BRCA mutation in the PROpel trial.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Olaparib; Prostate cancer; Abiraterone; Germline; Somatic cell; Germline mutation; PARP inhibitor; Oncology; Enzalutamide; Internal medicine; Placebo; Cancer; Mutation; Androgen receptor; Poly ADP ribose polymerase; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001260067,0.0007705322,0.001389451,0.0002796425,0.000195883,0.001001839,0.0004494699,0.0006384194,0.002790269],"category_scores_gemma":[0.001347027,0.0002940642,0.001120642,0.000329271,0.0004502664,0.0005482574,0.0003362528,0.001833096,0.0004621359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004605218,"about_ca_system_score_gemma":0.0007303509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005141692,"about_ca_topic_score_gemma":0.00150563,"domain_scores_codex":[0.9996087,0.0002523421,0.00002331889,0.00004228219,0.0000276089,0.00004564781],"domain_scores_gemma":[0.999424,0.0001808807,0.0001375373,0.00002443769,0.00002384154,0.0002094388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9502708,0.002149787,0.001639577,0.0006023465,0.0008365437,0.00006291595,0.00006073316,0.0007519852,0.003139414,0.0001029229,0.0007334759,0.03964953],"study_design_scores_gemma":[0.7474103,0.231024,0.01283875,0.0001550356,0.001983128,0.0002789632,0.00009867536,0.001954252,0.001481379,0.0005334861,0.002206996,0.00003516228],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890643,0.006624794,0.0002978123,0.0005482615,0.0002449402,0.0004905998,0.0007333174,0.00007374274,0.001922356],"genre_scores_gemma":[0.9951398,0.001928877,0.0004283666,0.0003680671,0.0002174099,0.0003862568,0.000614376,0.000007540213,0.0009091643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790269,"threshold_uncertainty_score":0.009334385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1323564119618907,"score_gpt":0.4739591583295819,"score_spread":0.3416027463676912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}