{"id":"W4407699857","doi":"10.1200/jco.2025.43.5_suppl.tps891","title":"ABLE-22: Safety and efficacy evaluation of nadofaragene firadenovec alone or in combination with chemotherapy or immunotherapy—A randomized, open-label, phase 2 study.","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; McGill University Health Centre","funders":"","keywords":"Medicine; Chemotherapy; Immunotherapy; Oncology; Open label; Internal medicine; Randomized controlled trial; Pharmacology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002113535,0.001633586,0.002097543,0.0004313684,0.0002882163,0.001164589,0.0009736407,0.001698093,0.007395918],"category_scores_gemma":[0.001173946,0.0006956895,0.001669928,0.0004004263,0.00108632,0.001216918,0.0003481102,0.002709401,0.001192023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006773649,"about_ca_system_score_gemma":0.001024385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005752778,"about_ca_topic_score_gemma":0.001302251,"domain_scores_codex":[0.9994361,0.0002899008,0.00002719858,0.000114453,0.00005317149,0.00007921917],"domain_scores_gemma":[0.9991159,0.0001872367,0.0002312349,0.00008001055,0.00005252843,0.0003331119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9213284,0.04088407,0.0009374345,0.0006354027,0.001195219,0.00006114235,0.00005522434,0.0004001147,0.009638941,0.00009788696,0.001114328,0.02365191],"study_design_scores_gemma":[0.7143486,0.279782,0.002250547,0.00002943808,0.0005196314,0.00007357322,0.00002203812,0.0004063754,0.001166439,0.00009937117,0.001280055,0.00002186566],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866173,0.00421062,0.0008694743,0.0003642317,0.0003089597,0.003842342,0.001694506,0.0001497373,0.00194285],"genre_scores_gemma":[0.9867601,0.002510998,0.001591992,0.0009032701,0.0003753637,0.003316666,0.001736568,0.00004257468,0.002762317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007395918,"threshold_uncertainty_score":0.02474183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1761127251326121,"score_gpt":0.5627920855961613,"score_spread":0.3866793604635492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}