{"id":"W4407701171","doi":"10.1200/jco.2025.43.5_suppl.tps432","title":"Darolutamide plus androgen-deprivation therapy (ADT) in patients with high-risk biochemical recurrence (BCR) of prostate cancer: A phase 3, randomized, double-blind, placebo-controlled study (ARASTEP).","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cégep de Lévis; McGill University","funders":"","keywords":"Medicine; Androgen deprivation therapy; Prostate cancer; Placebo; Internal medicine; Oncology; Biochemical recurrence; breakpoint cluster region; Androgen; Randomized controlled trial; Cancer; Urology; Prostatectomy; Hormone; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001376809,0.001264731,0.002166642,0.0005200389,0.0003305609,0.0008098315,0.0009147017,0.001241201,0.004419715],"category_scores_gemma":[0.0009553627,0.0005002054,0.001630945,0.000485259,0.0009213717,0.0007601355,0.0003256705,0.002255752,0.0006343113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005061687,"about_ca_system_score_gemma":0.001244091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008227956,"about_ca_topic_score_gemma":0.002374505,"domain_scores_codex":[0.9996191,0.0002021023,0.00002490207,0.0000620948,0.00003196809,0.00005975285],"domain_scores_gemma":[0.9993924,0.0001490204,0.0001459961,0.00004400902,0.00004307766,0.0002255312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9506051,0.019365,0.001005589,0.0009842712,0.000947117,0.00005227831,0.0000637338,0.000276408,0.005047799,0.00007925471,0.0005064079,0.02106703],"study_design_scores_gemma":[0.8803453,0.1166564,0.001745957,0.00002155811,0.0002704536,0.00003308995,0.00001640579,0.0001713788,0.0003477198,0.00005259654,0.0003301822,0.000009011131],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879133,0.004658352,0.0004692976,0.0003229187,0.0003117161,0.004251529,0.0008384666,0.0001139784,0.001120332],"genre_scores_gemma":[0.9873806,0.003211464,0.001570524,0.0008389532,0.000459897,0.003975421,0.0008391413,0.00001530428,0.001708765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004419715,"threshold_uncertainty_score":0.01478541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06419575208520342,"score_gpt":0.4573852924826808,"score_spread":0.3931895403974773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}