{"id":"W4407703483","doi":"10.21203/rs.3.rs-6011135/v1","title":"Early Alzheimer’s brain atrophy in entorhinal cortex is associated with HSD11B1-cortisol axis in APOE4 carriers","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; National Health Research Institutes; Eisai; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Alzheimer's Association","keywords":"Atrophy; Entorhinal cortex; Neuroscience; Cortex (anatomy); Medicine; Psychology; Internal medicine; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342102,0.0009100296,0.0004374708,0.000997617,0.0005358671,0.000722184,0.0004601945,0.0006943273,0.007484647],"category_scores_gemma":[0.001377381,0.0003835493,0.0004843581,0.0005848494,0.0004457093,0.0003706861,0.0003472167,0.0006658349,0.0005560759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973692,"about_ca_system_score_gemma":0.0001901163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00419422,"about_ca_topic_score_gemma":0.002631574,"domain_scores_codex":[0.9998577,0.00002468537,0.00001592467,0.00004973478,0.00001926139,0.00003263189],"domain_scores_gemma":[0.9993698,0.0001770797,0.0002467806,0.00006313533,0.00005506709,0.00008821138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008594683,0.0004019651,0.8972931,0.0001560745,0.000808921,0.02077565,0.001436805,0.000143079,0.05527048,0.0003821178,0.001160623,0.01357662],"study_design_scores_gemma":[0.00003033996,0.0001291251,0.9908515,0.00001614415,0.0002393998,0.005913956,0.000328992,0.0001472556,0.001533195,0.0003620022,0.0004349936,0.00001309753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998367,0.000378908,0.0002112968,0.000109526,0.00003168417,0.000004299259,0.0002656988,0.0000168615,0.0006147356],"genre_scores_gemma":[0.9979137,0.000153278,0.0001804866,0.00003293303,0.00004255324,0.000006392432,0.0002352892,0.0000207458,0.001414671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007484647,"threshold_uncertainty_score":0.02503866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0753339845514309,"score_gpt":0.3932841772634603,"score_spread":0.3179501927120294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}