{"id":"W4407710210","doi":"10.3390/cancers17040685","title":"Targeting Kinesins for Therapeutic Exploitation of Chromosomal Instability in Lung Cancer","year":2025,"lang":"en","type":"review","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Chromosome instability; Lung cancer; Genome instability; Cancer research; Medicine; Biology; Oncology; Genetics; DNA; DNA damage; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143083,0.0004896725,0.0006627852,0.001077874,0.0001897431,0.0005820029,0.0003649599,0.0006646402,0.001434869],"category_scores_gemma":[0.0001855674,0.0001444374,0.0003641855,0.0006168743,0.0002382206,0.0005416302,0.0004061396,0.001081398,0.0008380157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005047368,"about_ca_system_score_gemma":0.0003898554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920922,"about_ca_topic_score_gemma":0.001085799,"domain_scores_codex":[0.9999108,0.0000150513,0.00001113991,0.0000153331,0.00003322937,0.00001443211],"domain_scores_gemma":[0.9999405,0.00001752551,0.00001632152,0.000002186402,0.00001484682,0.000008501494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002674667,0.0001953934,0.0005763523,0.01630376,0.0001404669,0.001059481,0.0001611781,0.001562836,0.1385378,0.01172954,0.02424064,0.8052251],"study_design_scores_gemma":[0.00006832862,0.000564362,0.001863138,0.001235717,0.0002168294,0.003443039,0.0000660485,0.0008611334,0.03073654,0.003273029,0.9576188,0.00005292736],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003172314,0.9907737,0.002299709,0.0006038647,0.0003614831,0.00003414526,0.00006976322,0.00006610886,0.002618942],"genre_scores_gemma":[0.01493248,0.98011,0.001853867,0.0003578094,0.0002373349,0.000045522,0.0001317773,0.00001130212,0.002319779],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001434869,"threshold_uncertainty_score":0.004800081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258443877909269,"score_gpt":0.3364380151815421,"score_spread":0.3138535764024494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}