{"id":"W4407719386","doi":"10.1101/2025.02.17.25321407","title":"Pamrevlumab did not meet its primary endpoint for non-ambulatory patients with Duchenne Muscular Dystrophy: the LELANTOS-1 trial","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"FibroGen","keywords":"Duchenne muscular dystrophy; Ambulatory; Clinical endpoint; Medicine; Muscular dystrophy; Physical medicine and rehabilitation; Physical therapy; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001402307,0.0006100914,0.001446149,0.0001379963,0.0002720096,0.0008360588,0.0004406649,0.001116981,0.005458847],"category_scores_gemma":[0.001266961,0.0001414466,0.00119626,0.0001604736,0.00032993,0.0006060621,0.0002308298,0.001950775,0.0006120378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004369185,"about_ca_system_score_gemma":0.000477516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003055373,"about_ca_topic_score_gemma":0.001117665,"domain_scores_codex":[0.9994475,0.0003403126,0.0000347509,0.00006362071,0.00004583914,0.00006791113],"domain_scores_gemma":[0.9992756,0.0002730842,0.0001564036,0.00004485449,0.00004757046,0.0002025501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8540323,0.002962427,0.006442544,0.004109678,0.004227195,0.0003253079,0.0001431063,0.00114522,0.006829951,0.001051951,0.01465625,0.1040742],"study_design_scores_gemma":[0.8345048,0.1156176,0.02714499,0.0007628081,0.002638457,0.0006318657,0.0001051113,0.002515588,0.001784944,0.00135134,0.01289309,0.00004928581],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9354755,0.04197787,0.0007494698,0.002668002,0.0007464817,0.001127456,0.003360643,0.0001876069,0.01370688],"genre_scores_gemma":[0.9887826,0.003205206,0.0003946076,0.001721403,0.0003341928,0.0009367497,0.001734532,0.00001409416,0.002876717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005458847,"threshold_uncertainty_score":0.01826173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008955669958653779,"score_gpt":0.2334330334237781,"score_spread":0.2244773634651243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}