{"id":"W4407728142","doi":"10.1101/2025.02.14.638309","title":"Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Human Islet Research Network; National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania","keywords":"Transdifferentiation; Pancreas; Cell; Cell biology; Biology; Computer science; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005493253,0.0002787024,0.0005003712,0.0007075065,0.0004243164,0.0009216984,0.0003447659,0.0003744772,0.001971921],"category_scores_gemma":[0.0009297047,0.000159351,0.0005331484,0.0006707633,0.0002380285,0.0003249637,0.0009317909,0.000579221,0.0007809757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157481,"about_ca_system_score_gemma":0.0002930966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115289,"about_ca_topic_score_gemma":0.002311986,"domain_scores_codex":[0.9996365,0.00003697191,0.00002424284,0.0001893634,0.00006850817,0.00004446321],"domain_scores_gemma":[0.9994117,0.0001695759,0.00009300325,0.0001169308,0.0001400359,0.0000687872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006462787,0.00006544686,0.06201992,0.0003840034,0.000290895,0.0002239872,0.000263303,0.001576548,0.9113492,0.0004994414,0.001428392,0.02125251],"study_design_scores_gemma":[0.00005686203,0.000332691,0.6382517,0.0001579305,0.0003742183,0.001529605,0.0005815779,0.02040121,0.3082874,0.002871895,0.02706479,0.00009019341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9372509,0.002400497,0.03477992,0.0002001112,0.00005941125,0.00007086246,0.02310767,0.0003603188,0.001770291],"genre_scores_gemma":[0.9415167,0.0009628012,0.02329821,0.0002570837,0.00003930143,0.0001350377,0.03290903,0.0001620635,0.0007198203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001971921,"threshold_uncertainty_score":0.006596744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537698186585419,"score_gpt":0.2386263868409383,"score_spread":0.2232494049750841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}