{"id":"W4407744297","doi":"10.1097/fbp.0000000000000813","title":"The effect of Psilocybe cubensis alkaloids on depressive-like behavior in mice exposed to maternal separation with respect to hippocampal gene expression and DNA methylation of Slc6a4 and Nr3c1","year":2025,"lang":"en","type":"article","venue":"Behavioural Pharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Hippocampus; Internal medicine; Open field; Endocrinology; Hippocampal formation; Methylation; DNA methylation; Psychology; Chemistry; Gene expression; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003819694,0.0002035928,0.0003647977,0.0002614744,0.000130594,0.0000146002,0.0001332505,0.0001043527,0.0000220612],"category_scores_gemma":[0.00001925995,0.0001400496,0.00003589206,0.0002248041,0.0001117476,0.00004575344,0.0001065342,0.0001500958,0.000002410859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004117322,"about_ca_system_score_gemma":0.0000155751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002829557,"about_ca_topic_score_gemma":0.0002267148,"domain_scores_codex":[0.9984202,0.000410013,0.0003828218,0.0003814418,0.0001479061,0.0002575848],"domain_scores_gemma":[0.9991326,0.0003938248,0.0001551628,0.000167647,0.00007519551,0.00007555199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004923916,0.00008774322,0.2295287,0.00001341502,0.00005053383,0.00001501202,0.000763241,0.00003360203,0.7584038,0.00004054678,0.001046677,0.005092895],"study_design_scores_gemma":[0.002111763,0.001206257,0.4796747,0.00003373157,0.0001401225,0.000006477591,0.0001076933,0.000009258806,0.5165405,0.00001114626,0.00006773066,0.00009063956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971431,0.0005047984,0.00005346225,0.0004375335,0.0005413266,0.001070307,0.00002840505,0.0000149242,0.0002061302],"genre_scores_gemma":[0.9990857,0.0000277116,0.0001739691,0.0001672103,0.00002792782,0.000361843,0.000005777022,0.00001384109,0.0001359776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.250146,"threshold_uncertainty_score":0.5711055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442100573773621,"score_gpt":0.3717939348181444,"score_spread":0.3473729290804082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}