{"id":"W4407750550","doi":"10.32388/tl3ebk","title":"CHD3 Regulates BMP Signalling Response During Cranial Neural Crest Cell Specification","year":2025,"lang":"en","type":"preprint","venue":"Qeios","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Neural crest; Signalling; Cranial neural crest; Cell biology; Crest; Bone morphogenetic protein 2; Neuroscience; Biology; Genetics; In vitro; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007117052,0.0002028645,0.0001342134,0.0001816319,0.0001901655,0.0003391582,0.0001558515,0.000221762,0.002103751],"category_scores_gemma":[0.0001145916,0.0001297185,0.0001475301,0.0001024979,0.0002229478,0.0001384047,0.000302808,0.0004277099,0.0006932717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003482558,"about_ca_system_score_gemma":0.0002372966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405936,"about_ca_topic_score_gemma":0.002227907,"domain_scores_codex":[0.9999095,0.000007876853,0.000004422126,0.00001952787,0.00002813977,0.00003052275],"domain_scores_gemma":[0.9999561,0.000005940664,0.000008529467,0.000004353953,0.000007302822,0.00001772795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171917,0.000004261345,0.0007511202,0.00002038993,0.000002281699,0.0000762418,0.00001385427,0.00005907308,0.9972811,0.0002383398,0.00007939574,0.001356778],"study_design_scores_gemma":[0.00001447357,0.00003243244,0.02840448,0.000006036012,0.000007890356,0.0002010072,0.00004141709,0.001406908,0.9671521,0.0001879565,0.002539652,0.000005602185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812603,0.001497504,0.007117226,0.0001968127,0.0000542079,0.00002075988,0.001437035,0.0002555059,0.00816071],"genre_scores_gemma":[0.9934837,0.0003394305,0.001359853,0.0000363013,0.000005832081,0.00001054423,0.0007454257,0.00004527755,0.003973684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103751,"threshold_uncertainty_score":0.007037759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369724818868007,"score_gpt":0.2581909303608896,"score_spread":0.2444936821722095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}