{"id":"W4407750550","doi":"10.32388/tl3ebk","title":"CHD3 Regulates BMP Signalling Response During Cranial Neural Crest Cell Specification","year":2025,"lang":"en","type":"preprint","venue":"Qeios","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Neural crest; Signalling; Cranial neural crest; Cell biology; Crest; Bone morphogenetic protein 2; Neuroscience; Biology; Genetics; In vitro; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003531232,0.0002871939,0.0002230854,0.0001135788,0.00013592,0.0000872173,0.000325276,0.0005099504,0.00003325479],"category_scores_gemma":[0.0001175337,0.0003181972,0.0001607631,0.00007475148,0.00004572197,0.000002535799,0.0003325982,0.0003021342,0.00001225919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003993757,"about_ca_system_score_gemma":0.0001495745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002803981,"about_ca_topic_score_gemma":0.00001633718,"domain_scores_codex":[0.9982572,0.0002179915,0.0003942756,0.0006885756,0.0001809763,0.0002609602],"domain_scores_gemma":[0.9988561,0.00004223825,0.0002255559,0.000660707,0.0001366695,0.00007877619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000619001,0.00004730011,0.0005316042,0.0001257879,0.00002663337,0.000004336594,0.00006803381,0.01047277,0.9874091,0.000006759861,0.00008628733,0.0006023711],"study_design_scores_gemma":[0.0004246609,0.0001028475,0.0201536,0.00006206506,0.00004109231,9.741702e-7,0.00002119011,0.0008940973,0.9703427,0.0001912227,0.007413419,0.0003521368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993408,0.002802655,0.001323271,0.0002041168,0.0005788945,0.000407324,0.00008118922,0.00003361164,0.001160986],"genre_scores_gemma":[0.9926491,0.0006697171,0.0009739622,0.00003294209,0.0008001722,0.00004340217,0.0005637568,0.00003406385,0.004232905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.019622,"threshold_uncertainty_score":0.999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369724818868007,"score_gpt":0.2581909303608896,"score_spread":0.2444936821722095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}