{"id":"W4407752195","doi":"10.1038/s41523-025-00733-y","title":"Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer","year":2025,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Queen's University","funders":"National Cancer Institute; National Medical Research Council; Canadian Institutes of Health Research; Deutsche Krebshilfe; National Institute of General Medical Sciences; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Government of Canada; Deutsche Forschungsgemeinschaft; Department of Health and Social Care; Canadian Cancer Society Research Institute; National Institutes of Health; Ovarian Cancer Research Fund; Fondation du cancer du sein du Québec; Genome Canada; Cancer Research UK; NIHR Cambridge Biomedical Research Centre; European Commission; Breast Cancer Research Foundation","keywords":"Aromatase inhibitor; Aromatase; Breast cancer; Oncology; Medicine; Internal medicine; Cancer; Gene; Bioinformatics; Cancer research; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001115627,0.000325938,0.0003533779,0.00009475191,0.0001242522,0.00004510043,0.0001835485,0.0002188131,0.00006518486],"category_scores_gemma":[0.00001149422,0.000271524,0.0001050121,0.000247895,0.00007912882,0.000008925446,0.0001342722,0.0002008404,0.00001037349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002789421,"about_ca_system_score_gemma":0.0004298952,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02542547,"about_ca_topic_score_gemma":0.003796802,"domain_scores_codex":[0.9982896,0.0001412071,0.0003514308,0.0006699791,0.0001455063,0.0004022151],"domain_scores_gemma":[0.9992342,0.00001693238,0.0001122337,0.0004323742,0.00005259238,0.0001516572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003708361,0.0004825836,0.6624917,0.0000186266,0.0004720781,0.00004669089,0.0002226674,0.0004346044,0.3036372,0.000005935441,0.0006697287,0.03114739],"study_design_scores_gemma":[0.008143947,0.0002468717,0.8535644,0.0003252396,0.0003742239,0.00003741562,0.0004407616,0.0003317686,0.1342711,0.00006981649,0.001496128,0.0006983574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904862,0.00291961,0.000006081236,0.0037494,0.0003627781,0.0005028241,0.001838304,0.00002951566,0.0001053034],"genre_scores_gemma":[0.9972111,0.0007723744,0.0000517631,0.0004477282,0.0003245047,0.0004650708,0.0002583347,0.00003536675,0.0004337578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1910727,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02257743659329124,"score_gpt":0.3272573999102794,"score_spread":0.3046799633169881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}