{"id":"W4407752195","doi":"10.1038/s41523-025-00733-y","title":"Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer","year":2025,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Queen's University","funders":"National Cancer Institute; National Medical Research Council; Canadian Institutes of Health Research; Deutsche Krebshilfe; National Institute of General Medical Sciences; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Government of Canada; Deutsche Forschungsgemeinschaft; Department of Health and Social Care; Canadian Cancer Society Research Institute; National Institutes of Health; Ovarian Cancer Research Fund; Fondation du cancer du sein du Québec; Genome Canada; Cancer Research UK; NIHR Cambridge Biomedical Research Centre; European Commission; Breast Cancer Research Foundation","keywords":"Aromatase inhibitor; Aromatase; Breast cancer; Oncology; Medicine; Internal medicine; Cancer; Gene; Bioinformatics; Cancer research; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03361304,0.0009875845,0.001610998,0.001209754,0.00055027,0.001531431,0.001483737,0.001241175,0.001273042],"category_scores_gemma":[0.05376579,0.0002914481,0.002097131,0.001384157,0.002211477,0.001559404,0.001366025,0.001956762,0.0002009517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004781648,"about_ca_system_score_gemma":0.00138416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004289605,"about_ca_topic_score_gemma":0.004755293,"domain_scores_codex":[0.9902686,0.006866664,0.0006565229,0.001292549,0.0007068613,0.0002088259],"domain_scores_gemma":[0.9485779,0.04237741,0.001341154,0.004764068,0.002103165,0.0008364191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004774451,0.0003979559,0.6902984,0.001071931,0.008301152,0.005845901,0.002130855,0.004816867,0.01210354,0.01235818,0.008899082,0.2490017],"study_design_scores_gemma":[0.002003182,0.00511727,0.8471271,0.00155364,0.01043673,0.005872041,0.002648135,0.01612737,0.005633734,0.07727671,0.02592297,0.000281201],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8538812,0.04170014,0.03797655,0.05881584,0.001153829,0.0001296402,0.0009262636,0.0001593853,0.005257158],"genre_scores_gemma":[0.9701052,0.007569733,0.01184597,0.007768074,0.001724653,0.00008134772,0.0002492178,0.000064583,0.0005912562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03361304,"threshold_uncertainty_score":0.1777649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02257743659329124,"score_gpt":0.3272573999102794,"score_spread":0.3046799633169881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}