{"id":"W4407752952","doi":"10.1002/anie.202423275","title":"Manganese‐Ketenimine Intermediates as Active Catalysts in the Michael Addition of Unactivated Nitriles to α,β‐Unsaturated Ketones","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation","keywords":"Propionitrile; Chemistry; Acetonitrile; Nitrile; Catalysis; Manganese; Trifluoromethyl; Propargyl; Organic chemistry; Electrophile; Michael reaction; Ketenimine; Steric effects; Reactivity (psychology); Medicinal chemistry; Combinatorial chemistry; Alkyl","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599209,0.0001787735,0.00020683,0.0005401638,0.0000535207,0.00003619339,0.0004236235,0.0001412194,0.0007178386],"category_scores_gemma":[0.000810964,0.0001492713,0.0001148857,0.001013986,0.00006895649,0.0002506514,0.00006927991,0.0002069802,0.00003427502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320654,"about_ca_system_score_gemma":0.00006577833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003441684,"about_ca_topic_score_gemma":0.00009894143,"domain_scores_codex":[0.9986764,0.00002473426,0.0003996524,0.0002931833,0.0004454377,0.0001605821],"domain_scores_gemma":[0.9987814,0.0003737627,0.0002022878,0.0002133535,0.0003852661,0.000043918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004562497,0.0003992266,0.0005253365,0.00008255408,0.0003592489,0.0000220711,0.001780718,0.00002419452,0.973242,0.0005877544,0.01641317,0.006107426],"study_design_scores_gemma":[0.0005985175,0.00001467916,0.002131176,0.0001562777,0.00004734646,0.000009497805,0.002385104,0.00006448866,0.9889031,0.0005688187,0.004986457,0.0001345073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502878,0.00007284737,0.0001906358,0.00326317,0.0004270901,0.0001695451,0.0005504497,0.00006237709,0.0449761],"genre_scores_gemma":[0.9921373,0.00004497821,0.00002618786,0.0005142022,0.0002938503,0.0001350785,0.005697552,0.00001162844,0.001139282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04383682,"threshold_uncertainty_score":0.785983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007412835869985483,"score_gpt":0.2654766314203179,"score_spread":0.2580637955503324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}