{"id":"W4407753426","doi":"10.1186/s13195-025-01692-z","title":"The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity","year":2025,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Hjärnfonden; University College London; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; European Commission; Fondation Brain Canada; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Association; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Alzheimer's Drug Discovery Foundation","keywords":"Medicine; Biomarker; Renal function; Internal medicine; Dementia; Kidney disease; Oncology; Creatinine; Cohort; Cystatin C; Neurology; Pathology; Disease; Gastroenterology; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253112,0.0002275299,0.000290004,0.000311997,0.0007363935,0.00008258566,0.0002853445,0.0000949314,0.00006991711],"category_scores_gemma":[0.001087107,0.0001471967,0.0004877908,0.0008003834,0.0003816517,0.0001230188,0.00007249424,0.000293857,0.00001052777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008532203,"about_ca_system_score_gemma":0.003086494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003225414,"about_ca_topic_score_gemma":0.000004648575,"domain_scores_codex":[0.9977505,0.0002875662,0.0003576489,0.0004688542,0.0004407605,0.0006946345],"domain_scores_gemma":[0.9955671,0.00178405,0.00009568902,0.00100393,0.0006827365,0.0008664955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02483211,0.005127146,0.2242922,0.0001263189,0.04187753,0.000006084852,0.0002301271,0.00001516546,0.08078685,0.006188375,0.2467779,0.3697402],"study_design_scores_gemma":[0.01219079,0.005132966,0.8956355,0.0006295891,0.004172538,0.000002834272,0.0001891421,0.001509919,0.03909922,0.01261084,0.02842939,0.0003972077],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7417595,0.1761362,0.0003296393,0.05724239,0.0004586031,0.01150723,0.001711318,0.0003237978,0.01053132],"genre_scores_gemma":[0.9957687,0.001826528,0.00003442894,0.0009724095,0.0002120409,0.0008015124,0.0002322445,0.00003791222,0.0001142547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6713433,"threshold_uncertainty_score":0.6002508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08926995974367784,"score_gpt":0.4281450500785648,"score_spread":0.3388750903348869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}