{"id":"W4407758752","doi":"10.1002/psc.70007","title":"Cancer‐Targeting Peptides Functionalized With Polyarginine Enables GRP78‐Dependent Cell Uptake and siRNA Delivery Within the DU145 Prostate Cancer Cells","year":2025,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"DU145; Cell-penetrating peptide; Small interfering RNA; RNA interference; Endosome; Cancer cell; Endocytosis; Chemistry; Cell; Peptide; Internalization; Cell biology; Gene knockdown; Cancer research; Cancer; Biochemistry; Biology; RNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137418,0.0002630772,0.0001815901,0.0000819405,0.00009025259,0.0002240555,0.0001559678,0.0002441865,0.0002297405],"category_scores_gemma":[0.00009328611,0.00009047344,0.00013827,0.00007372234,0.0001266209,0.0001690498,0.0001362125,0.000232552,0.0001449933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729191,"about_ca_system_score_gemma":0.0001291368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005515949,"about_ca_topic_score_gemma":0.0007862502,"domain_scores_codex":[0.9998912,0.0000210262,0.000008634634,0.0000260913,0.00003522764,0.00001781845],"domain_scores_gemma":[0.9999508,0.000008886076,0.00001568995,0.000004768196,0.000008810594,0.00001105913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001051582,0.000004009124,0.00002520743,0.00001695563,0.0000010907,0.00002386334,0.00000653747,0.00004605428,0.9993111,0.00003415141,0.000005736412,0.0005148289],"study_design_scores_gemma":[0.00000355251,0.0001132537,0.0005692287,0.000001372779,0.000005886431,0.0001437292,0.000007656733,0.0006657814,0.9974639,0.000009897726,0.001012175,0.000003406733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915577,0.001801493,0.00512506,0.00004185446,0.00001791933,0.00002968095,0.00006561787,0.0000403547,0.001320344],"genre_scores_gemma":[0.9932227,0.0007717935,0.004796793,0.0000323653,0.000007510293,0.0000145202,0.00007965157,0.000007238348,0.001067367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005515949,"threshold_uncertainty_score":0.001254559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006643073509904637,"score_gpt":0.2420457577618841,"score_spread":0.2354026842519795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}