{"id":"W4407758752","doi":"10.1002/psc.70007","title":"Cancer‐Targeting Peptides Functionalized With Polyarginine Enables GRP78‐Dependent Cell Uptake and siRNA Delivery Within the DU145 Prostate Cancer Cells","year":2025,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"DU145; Cell-penetrating peptide; Small interfering RNA; RNA interference; Endosome; Cancer cell; Endocytosis; Chemistry; Cell; Peptide; Internalization; Cell biology; Gene knockdown; Cancer research; Cancer; Biochemistry; Biology; RNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000832336,0.0001685043,0.0001831657,0.0001204208,0.0003229693,0.0001408893,0.0004245951,0.00004803098,0.00003611317],"category_scores_gemma":[0.00005564681,0.0001013002,0.00006530024,0.0002840355,0.0004520428,0.00004658335,0.0001445663,0.000199828,0.000001404061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005209048,"about_ca_system_score_gemma":0.001062601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002796834,"about_ca_topic_score_gemma":0.0002915105,"domain_scores_codex":[0.9986392,0.00004346407,0.000382616,0.0003040589,0.0003496897,0.0002809174],"domain_scores_gemma":[0.9986938,0.00002696417,0.0004028261,0.0001766811,0.0005989333,0.0001007798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003455264,0.00003035285,0.005521365,0.00002516632,0.00005534797,0.000008783066,0.0002342223,0.004154916,0.9853433,0.00002037996,0.002698283,0.001562319],"study_design_scores_gemma":[0.0009959184,0.0005070998,0.006729206,0.0002498259,0.00008887338,0.00004105851,0.002099429,0.0002928384,0.9803934,0.00009135855,0.008288447,0.0002225175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901609,0.007898622,0.0001671661,0.0006335114,0.0004929162,0.0001246408,0.0000160584,0.000003634372,0.0005025527],"genre_scores_gemma":[0.989719,0.003407839,0.0007339241,0.0006273005,0.0002094452,0.00001154487,0.000001506513,0.000009162824,0.005280275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005590164,"threshold_uncertainty_score":0.4130904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006643073509904637,"score_gpt":0.2420457577618841,"score_spread":0.2354026842519795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}