{"id":"W4407762353","doi":"10.1007/s12035-025-04748-1","title":"PARP-16 regulates the PERK and IRE-1α Mediated Unfolded Protein Response in Japanese Encephalitis Virus–Infected Neural Stem/Progenitor Cells","year":2025,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Manitoba","funders":"Science and Engineering Research Board","keywords":"Neural stem cell; Progenitor cell; Virology; Stem cell; Unfolded protein response; Virus; Biology; Cell biology; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00023176,0.0003309925,0.0003066053,0.0001156737,0.000115831,0.00004626614,0.0003383673,0.0002793587,0.00001319468],"category_scores_gemma":[0.0003211823,0.000254774,0.0001252188,0.0002896428,0.0003781361,0.000005791139,0.0002913378,0.0002121709,0.000008142739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000209947,"about_ca_system_score_gemma":0.000112778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001184968,"about_ca_topic_score_gemma":0.0000669597,"domain_scores_codex":[0.9971473,0.001168664,0.0003920435,0.0007111551,0.00009653423,0.0004842703],"domain_scores_gemma":[0.9989361,0.0001382528,0.0001092098,0.0006165263,0.00007811352,0.0001217878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001233495,0.00008197574,0.00110447,0.00003303781,0.00004850958,0.00008975693,0.00005713652,0.00005728487,0.9965861,0.0000569152,0.0003613335,0.000290027],"study_design_scores_gemma":[0.001602219,0.000480294,0.006024453,0.00003728673,0.00004624644,0.00004443371,0.0001705713,0.0002192688,0.9880454,0.00008287241,0.002919865,0.0003271041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963549,0.001527093,0.00001637447,0.0008130273,0.0001989931,0.0007967768,0.00007839654,0.00003364871,0.0001807241],"genre_scores_gemma":[0.9980448,0.0000924963,0.00001923358,0.000985743,0.00003053812,0.0001961447,0.0001302037,0.00002973803,0.0004710543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008540672,"threshold_uncertainty_score":0.9999905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003938370866711101,"score_gpt":0.216875181446003,"score_spread":0.2129368105792919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}