{"id":"W4407762879","doi":"10.1016/j.ijgc.2025.101703","title":"Durvalumab Plus Carboplatin/Paclitaxel Followed By Durvalumab With/Without Olaparib In Endometrial Cancer: Exploratory Analyses Of Histology, Biomarker Heterogeneity And Efficacy In The DUO-E Mismatch Repair Proficient Subpopulation","year":2025,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"Durvalumab; Medicine; Olaparib; Paclitaxel; Carboplatin; Endometrial cancer; Biomarker; Oncology; Cancer; Internal medicine; Cisplatin; Chemotherapy; Immunotherapy; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012052,0.0002660204,0.0008622486,0.0001810963,0.0001285474,0.0005040075,0.0002367219,0.0002780742,0.000982467],"category_scores_gemma":[0.001262459,0.0001508868,0.0007398793,0.0002225379,0.0002450321,0.0005073282,0.0002265968,0.000700608,0.0001276128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004304186,"about_ca_system_score_gemma":0.0004638369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006591722,"about_ca_topic_score_gemma":0.001794146,"domain_scores_codex":[0.9996438,0.0001636289,0.00002323573,0.00006774572,0.0000341091,0.00006746384],"domain_scores_gemma":[0.999548,0.0001893989,0.0000933457,0.00005333922,0.00001531138,0.0001006786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7129385,0.004475793,0.1247226,0.0003628161,0.004294461,0.0002180196,0.0002878162,0.002310189,0.01571675,0.0003220939,0.0006246959,0.1337262],"study_design_scores_gemma":[0.05685201,0.2593054,0.6481327,0.0001560322,0.008043394,0.0009706994,0.0007831512,0.009178052,0.009625169,0.001206754,0.00566722,0.00007948616],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987789,0.0008440253,0.00004373381,0.00003403599,0.000009077152,0.00002006678,0.00007964705,0.000002684092,0.000187905],"genre_scores_gemma":[0.9992833,0.0002729665,0.0001022417,0.00004895794,0.00001453114,0.00002062212,0.0001180375,0.000001586842,0.0001378294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012052,"threshold_uncertainty_score":0.005352318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07644395857801443,"score_gpt":0.4110237908825988,"score_spread":0.3345798323045844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}