{"id":"W4407764676","doi":"10.1186/s13058-025-01963-5","title":"Genomic alterations are associated with response to aromatase inhibitor therapy for ER-positive postmenopausal ductal carcinoma in situ: (CALGB 40903, Alliance)","year":2025,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Breast Cancer Research Foundation","keywords":"Aromatase; Medicine; Oncology; Aromatase inhibitor; Ductal carcinoma; Surgical oncology; Internal medicine; Postmenopausal women; In situ; Breast cancer; Gynecology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003314549,0.0001772726,0.0002925709,0.0002700434,0.0001296651,0.0002526866,0.0001652771,0.0001706793,0.001287556],"category_scores_gemma":[0.0004779538,0.0001181677,0.0001608761,0.0003920453,0.0001556172,0.00006667118,0.0001282518,0.0002276158,0.0001249081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175444,"about_ca_system_score_gemma":0.0002567052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009274323,"about_ca_topic_score_gemma":0.002178692,"domain_scores_codex":[0.9998542,0.00004862111,0.00001104274,0.00003319956,0.0000334759,0.00001937492],"domain_scores_gemma":[0.9997573,0.00004974843,0.0001276197,0.00001500432,0.00001566957,0.0000346914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05352905,0.001398432,0.6861941,0.0004534736,0.0008421761,0.0002513473,0.0001253257,0.001297379,0.1806026,0.00007311814,0.001404734,0.07382832],"study_design_scores_gemma":[0.001300714,0.00463052,0.9857142,0.000009900596,0.0002858156,0.0005148865,0.00004306619,0.0006882099,0.005886574,0.00004812079,0.0008712117,0.000006841317],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989428,0.0003681631,0.00008403561,0.00002525027,0.000002137668,0.00002108236,0.0004073752,0.000009037737,0.0001400479],"genre_scores_gemma":[0.9981018,0.0001769195,0.0003369213,0.00004974539,0.0000059256,0.00003475303,0.001080667,0.000002670012,0.0002105739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287556,"threshold_uncertainty_score":0.00430727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02317355908565214,"score_gpt":0.34217548034693,"score_spread":0.3190019212612779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}