{"id":"W4407765430","doi":"10.1111/mmi.15347","title":"Future Directions of the Prokaryotic Chromosome Field","year":2025,"lang":"en","type":"review","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Leiden","keywords":"Biology; Field (mathematics); Chromosome; Computational biology; Genetics; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001694132,0.0007469623,0.0009852457,0.001860488,0.0004802968,0.002031602,0.001008312,0.002840915,0.006646781],"category_scores_gemma":[0.001729443,0.0002407025,0.0004982706,0.001702812,0.001572717,0.004134262,0.001333472,0.0033689,0.003054744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001764197,"about_ca_system_score_gemma":0.002728887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001197124,"about_ca_topic_score_gemma":0.001567713,"domain_scores_codex":[0.9995866,0.0001007167,0.00004244132,0.00006523082,0.0001442106,0.00006085889],"domain_scores_gemma":[0.9985144,0.0008951805,0.00008518325,0.00003673594,0.0003125523,0.0001559536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001505205,0.00006914346,0.0001752172,0.01596252,0.00005092814,0.0004273281,0.000271535,0.0004718959,0.002558667,0.05022265,0.09529128,0.8343485],"study_design_scores_gemma":[0.000006508643,0.00003757052,0.0002061496,0.001530785,0.00001321947,0.000457878,0.00009879182,0.00003194681,0.0001396913,0.005589614,0.9918796,0.000008268488],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004455037,0.9970104,0.00006817887,0.00147932,0.0007244744,8.883428e-7,0.000004020173,0.000004089784,0.0006642131],"genre_scores_gemma":[0.0009086648,0.9948878,0.0001765016,0.001837117,0.001194412,0.000003253228,0.00001760508,0.000002576745,0.0009720885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006646781,"threshold_uncertainty_score":0.02223569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005228077019869244,"score_gpt":0.2412435243106483,"score_spread":0.236015447290779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}