{"id":"W4407766055","doi":"10.1021/acs.biochem.4c00492","title":"Role of the Palmitoyl Group and of the Amphipathic α Helix in the Membrane Binding of the C-Terminus of G-Protein Receptor Kinase 4α/β","year":2025,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Fonds de Recherche du Québec - Santé; Fondation des Maladies de l'Oeil","keywords":"Chemistry; Helix (gastropod); N-terminus; Amphiphile; Receptor; Biophysics; Cell biology; Stereochemistry; Biochemistry; Biology; Peptide sequence; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002210462,0.0002801853,0.0001642304,0.0001086519,0.0001931979,0.0002307966,0.0001905753,0.0003718552,0.000715199],"category_scores_gemma":[0.0002925561,0.0001561133,0.0002646031,0.00007988839,0.0003062627,0.0003443634,0.0002631021,0.0005428402,0.0003462388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146752,"about_ca_system_score_gemma":0.0001695892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003268331,"about_ca_topic_score_gemma":0.0002354005,"domain_scores_codex":[0.9998339,0.00003679702,0.00001379837,0.00003330474,0.00004203767,0.00004004512],"domain_scores_gemma":[0.9998036,0.00003672939,0.00007540502,0.00001586853,0.00002527455,0.00004311525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002187297,0.000009594962,0.0003417196,0.00003347687,0.000005183217,0.0000577784,0.00001450715,0.00011989,0.9982215,0.0001197531,0.000008764092,0.0008491462],"study_design_scores_gemma":[0.0000201972,0.0001909456,0.007452934,0.000008915856,0.00001981687,0.0003609852,0.00003761739,0.001683745,0.9889234,0.0001293631,0.001160361,0.00001172965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956957,0.001067919,0.002299623,0.000063488,0.00001195942,0.00001479697,0.00007417142,0.00001548528,0.0007568231],"genre_scores_gemma":[0.9971288,0.0003890985,0.001679411,0.00005466978,0.000005223852,0.00001626297,0.0001017289,0.000008345567,0.0006165801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000715199,"threshold_uncertainty_score":0.00239259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00417495324824755,"score_gpt":0.2054989316734328,"score_spread":0.2013239784251852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}