{"id":"W4407767321","doi":"10.3390/v17030295","title":"Viral Appropriation of Specificity Protein 1 (Sp1): The Role of Sp1 in Human Retro- and DNA Viruses in Promoter Activation and Beyond","year":2025,"lang":"en","type":"review","venue":"Viruses","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; University of Alberta","keywords":"Biology; Computational biology; Epigenetics; Sp1 transcription factor; Transcription factor; Promoter; DNA; Transcription (linguistics); Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000387287,0.00050905,0.0006459124,0.001185112,0.0002037187,0.0005764529,0.0005199017,0.0007455873,0.00196052],"category_scores_gemma":[0.0004335331,0.0001902839,0.0002763573,0.001014247,0.0003796056,0.0009149431,0.0004564183,0.001451729,0.001282138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004685638,"about_ca_system_score_gemma":0.0006616936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007024077,"about_ca_topic_score_gemma":0.001280145,"domain_scores_codex":[0.9999051,0.00001757225,0.00001312767,0.00001977869,0.00003309888,0.00001126685],"domain_scores_gemma":[0.9998193,0.00009330161,0.00002161582,0.000005296786,0.00004145157,0.00001902871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007339943,0.00003959719,0.0001845765,0.01407438,0.00006411874,0.0002429002,0.00006862824,0.0003656143,0.005043481,0.006982345,0.02602226,0.9468387],"study_design_scores_gemma":[0.000008479565,0.00007425554,0.0005442632,0.001515822,0.00004346337,0.001259877,0.00004193802,0.00006427795,0.0009833447,0.00177451,0.9936776,0.00001215114],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001504193,0.9981498,0.0001691853,0.0002780587,0.0002305297,0.000002995621,0.0000141184,0.000005047772,0.000999924],"genre_scores_gemma":[0.0007940789,0.9979222,0.0001878275,0.0002078008,0.0001694388,0.000004545462,0.00002745021,0.000001498801,0.0006851881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00196052,"threshold_uncertainty_score":0.006558597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02407543655927309,"score_gpt":0.3088840130592588,"score_spread":0.2848085764999858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}