{"id":"W4407768642","doi":"10.1183/13993003.01875-2024","title":"Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response","year":2025,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University; University of British Columbia Hospital; St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Lung Association; AstraZeneca Canada","keywords":"Eosinophilia; Medicine; Immunology; Airway; Eosinophil; Bronchoalveolar lavage; COPD; Inflammation; Asthma; Internal medicine; Lung; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003553392,0.000139,0.0004113531,0.0003987096,0.0001740041,0.0003408614,0.0001004933,0.0002582449,0.00106183],"category_scores_gemma":[0.0004467766,0.00009227257,0.0002717289,0.0004601969,0.0001797469,0.0001091706,0.0001749254,0.0002782938,0.0001849884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759146,"about_ca_system_score_gemma":0.0001770506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003716794,"about_ca_topic_score_gemma":0.0006164035,"domain_scores_codex":[0.9997571,0.00006686775,0.0000184989,0.00004343775,0.00006936866,0.00004471249],"domain_scores_gemma":[0.9997751,0.00006532759,0.00007956258,0.00001212418,0.00003816242,0.00002966273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006459476,0.0001975268,0.1864407,0.0005191716,0.0002483787,0.0003886547,0.0002316283,0.0003333194,0.7834718,0.00007783152,0.0003741629,0.02125746],"study_design_scores_gemma":[0.0001046359,0.001575852,0.9585053,0.00005313254,0.0002185561,0.0006812312,0.0002818289,0.0009690377,0.03620583,0.000155241,0.001238259,0.00001119817],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965764,0.001829621,0.0004746102,0.00006391684,0.000008685625,0.00003668755,0.0006956497,0.000007029448,0.0003073728],"genre_scores_gemma":[0.9958157,0.001374297,0.0009093827,0.0001194335,0.00001652604,0.00008129593,0.001302926,0.000004457635,0.0003760698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106183,"threshold_uncertainty_score":0.003552139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941727741848411,"score_gpt":0.2876296832475537,"score_spread":0.2682124058290696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}