{"id":"W4407778164","doi":"10.1101/2025.02.17.25322322","title":"Clinical Progression on CDR-SB <sup>©</sup> : Progression Free Time at Each 0.5-unit Level in Dominantly Inherited and Sporadic Alzheimer’s Disease Populations","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Instituto de Salud Carlos III; Canadian Institutes of Health Research; McDonnell Center for Systems Neuroscience; Genentech; National Institutes of Health; Fleni; IXICO; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; Washington University in St. Louis; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Ministry of Science and ICT, South Korea; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Disease; Medicine; Neuroscience; Biology; Genetics; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01407687,0.0005886705,0.0004701705,0.001196231,0.0001860788,0.001068164,0.0005002181,0.0004046593,0.003567226],"category_scores_gemma":[0.01464429,0.0001294957,0.0009316271,0.001038466,0.000434784,0.0006891001,0.0005256793,0.0006187842,0.0006612114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006971825,"about_ca_system_score_gemma":0.0007573983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005702951,"about_ca_topic_score_gemma":0.004665145,"domain_scores_codex":[0.9979232,0.0009669582,0.0001682144,0.0004712859,0.000346265,0.0001240408],"domain_scores_gemma":[0.9921439,0.004232654,0.00195295,0.0007554701,0.0006212881,0.0002938439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02382449,0.0002406697,0.7580742,0.001374876,0.003716332,0.000240779,0.001004944,0.01254735,0.005359692,0.005079098,0.01151986,0.1770177],"study_design_scores_gemma":[0.0005365039,0.001938803,0.9499174,0.0001772098,0.001480119,0.000838321,0.0003281235,0.01581053,0.00674051,0.006276774,0.01586685,0.00008885314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9268473,0.01024441,0.02773655,0.0005834613,0.0001750069,0.0003164104,0.0259553,0.0005197101,0.007621816],"genre_scores_gemma":[0.9774919,0.0005000557,0.008707941,0.0001076468,0.0000472763,0.0002404456,0.01093766,0.0001109531,0.001856007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01407687,"threshold_uncertainty_score":0.0744465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1497458591766364,"score_gpt":0.434840502458949,"score_spread":0.2850946432823126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}