{"id":"W4407778183","doi":"10.1002/jev2.70042","title":"Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress","year":2025,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for Exercise Medicine, University of Alabama at Birmingham; Kempestiftelserna; Umeå Universitet; Kempe Foundation; Västerbotten Läns Landsting; Fondation pour la Recherche Médicale; Carl von Ossietzky Universität Oldenburg; Université Laval","keywords":"Histone; Cell biology; Chromatin; Biology; Secretion; Nucleosome; Histone-modifying enzymes; Extracellular vesicle; Microvesicles; Biochemistry; DNA; Gene; microRNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009761809,0.0005810783,0.0006558223,0.0003299461,0.0002454712,0.0001402455,0.001150141,0.0005095818,0.0001883103],"category_scores_gemma":[0.0003282293,0.0005699198,0.0005968154,0.0004295301,0.0003623704,0.00005582167,0.0002251133,0.0005531905,0.00004179346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001055206,"about_ca_system_score_gemma":0.0005109331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002643615,"about_ca_topic_score_gemma":0.000006464186,"domain_scores_codex":[0.9960462,0.0003741705,0.001508683,0.0006831603,0.0007045743,0.0006832103],"domain_scores_gemma":[0.9968988,0.00006771794,0.001078075,0.001028978,0.0005027573,0.0004236916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005600471,0.001081079,0.0005243225,0.0002345003,0.0002458595,0.0003436467,0.00008004285,0.0002826581,0.9831577,0.0006930887,0.01066244,0.002134637],"study_design_scores_gemma":[0.001877127,0.0004540418,0.0001552247,0.0002023933,0.0002261267,0.0001271916,0.0002569596,0.00009010109,0.8853611,0.0006451269,0.1101075,0.0004971053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8416776,0.1486629,0.006576866,0.0006585341,0.0005353247,0.0005123508,0.0000499966,0.00003586433,0.001290588],"genre_scores_gemma":[0.9587585,0.001115913,0.003089091,0.0001308479,0.0003901047,0.00002074225,0.0001137556,0.0001046655,0.03627632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.147547,"threshold_uncertainty_score":0.9996752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005021554780005492,"score_gpt":0.2327992292062414,"score_spread":0.2277776744262359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}