{"id":"W4407779590","doi":"10.1038/s41467-025-56678-0","title":"Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Diet and metabolism studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; International Council for Canadian Studies; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Fonds De La Recherche Scientifique - FNRS; Fonds National de la Recherche Luxembourg; Action LIONS Vaincre le Cancer; Fondation Cancer; National Institutes of Health; Université du Luxembourg","keywords":"Microbiome; Colorectal cancer; Ketogenic diet; Immune system; Biology; Cancer research; Stearate; Gut flora; Cancer; Prebiotic; Gut microbiome; Endocrinology; Internal medicine; Immunology; Medicine; Chemistry; Biochemistry; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001313191,0.0002236107,0.0002310817,0.0003526825,0.0001687789,0.0002921442,0.0001310592,0.0002016382,0.001390812],"category_scores_gemma":[0.00018062,0.00009534025,0.0001831897,0.0002067289,0.0002547136,0.0002240546,0.0002473911,0.0004587089,0.0002126778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506098,"about_ca_system_score_gemma":0.0002536231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005309107,"about_ca_topic_score_gemma":0.001294001,"domain_scores_codex":[0.9999062,0.00002490084,0.000007974009,0.0000133504,0.0000278941,0.00001965556],"domain_scores_gemma":[0.9998618,0.00001317078,0.00003508994,0.000015742,0.00001980124,0.00005435733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004001638,0.0003478561,0.00170965,0.0001354213,0.0000330383,0.00005474357,0.00003660677,0.00004603479,0.9839272,0.000107029,0.0001316207,0.009469099],"study_design_scores_gemma":[0.0003120321,0.01089353,0.07735245,0.00006911781,0.0001619726,0.0004700099,0.0002885036,0.0005335785,0.8995274,0.0002409168,0.01013116,0.00001947417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964766,0.001537373,0.0005715487,0.0001917047,0.00004157855,0.00002313855,0.0001512645,0.00004765459,0.0009591074],"genre_scores_gemma":[0.9945762,0.00162947,0.001288065,0.0001629192,0.00002290312,0.00003213696,0.0002483761,0.00002053166,0.002019332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390812,"threshold_uncertainty_score":0.004652739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307288697542455,"score_gpt":0.3433994758793885,"score_spread":0.320326588903964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}