{"id":"W4407779808","doi":"10.3390/pathogens14030207","title":"Computational and Population-Based HLA Permissiveness to HIV Drug Resistance-Associated Mutations","year":2025,"lang":"en","type":"article","venue":"Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; AIDS Vancouver","funders":"","keywords":"Human leukocyte antigen; CTL*; Permissiveness; Allele; Immunology; Population; Biology; Drug resistance; Genetics; Human immunodeficiency virus (HIV); Cytotoxic T cell; Virology; CD8; Antigen; Virus; Medicine; Gene; Viral replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001126342,0.0003762383,0.0007546117,0.0008035719,0.0007416751,0.001326797,0.001357974,0.001017972,0.003012978],"category_scores_gemma":[0.005499726,0.0004301909,0.0007796781,0.0006314826,0.0007820398,0.0007656468,0.0007976013,0.0007961732,0.0001996495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001115504,"about_ca_system_score_gemma":0.001280178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02157601,"about_ca_topic_score_gemma":0.01745065,"domain_scores_codex":[0.999698,0.0001625845,0.00001079575,0.00005240258,0.00002960825,0.0000465633],"domain_scores_gemma":[0.9976605,0.001805337,0.0001265923,0.0001220777,0.0001535341,0.0001319786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.00005033856,0.00003772353,0.004908071,0.00001809734,0.00004638825,0.000041278,0.00003581958,0.9909998,0.0001291499,0.001958065,0.000265559,0.001509787],"study_design_scores_gemma":[0.00001608928,0.00001212607,0.000592744,0.000002752924,0.00001035252,0.000006893659,0.00002355084,0.9976664,0.00003664976,0.001530289,0.00009821763,0.000004067782],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656562,0.0001712812,0.02398988,0.0009122575,0.00007085808,0.00004233276,0.0005824756,0.0002286424,0.008345909],"genre_scores_gemma":[0.9906889,0.00006861123,0.00786423,0.0001720565,0.00002729004,0.00006774065,0.0002816225,0.00003900926,0.0007904555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02157601,"threshold_uncertainty_score":0.04290086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008739369973264324,"score_gpt":0.2712289262575822,"score_spread":0.2624895562843179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}