{"id":"W4407780552","doi":"10.7554/elife.99141.3","title":"Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology","year":2025,"lang":"en","type":"article","venue":"eLife","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Association","keywords":"Motor neuron; Pathology; Central nervous system; Peripheral; Peripheral nervous system; Biology; Neuroscience; Nervous system; Enteric nervous system; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140741,0.0001204818,0.0002709314,0.0001031289,0.00004816041,0.00001121967,0.00006358344,0.00007590042,0.00005980505],"category_scores_gemma":[0.00004860352,0.00009906831,0.00009325182,0.0001140162,0.0000802056,0.00001567118,0.00004232742,0.0001545586,0.000009334001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007345436,"about_ca_system_score_gemma":0.00009888031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001075038,"about_ca_topic_score_gemma":0.000008817449,"domain_scores_codex":[0.9988855,0.0001531412,0.0001794452,0.0002544431,0.0002554929,0.0002720043],"domain_scores_gemma":[0.999478,0.0000420215,0.00003540658,0.0002460628,0.00007793055,0.0001205133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004155087,0.001101214,0.3964267,0.001543076,0.000350032,0.001594163,0.0008058775,0.0002013878,0.4399409,0.003073993,0.005562498,0.1452451],"study_design_scores_gemma":[0.001211045,0.001427402,0.992214,0.00007083158,0.00002790866,0.00006746657,0.00008858268,0.0004633522,0.001619795,0.000001714723,0.002741349,0.00006652688],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956178,0.001802476,0.0005395034,0.0001587765,0.000205423,0.0004676657,0.00001307507,0.00003353618,0.001161721],"genre_scores_gemma":[0.9984894,0.0007533804,0.00005694803,0.00007206407,0.00008640384,0.00001089978,0.00001244954,0.00001605411,0.0005023691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5957873,"threshold_uncertainty_score":0.4039889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750160695388383,"score_gpt":0.3053434426623088,"score_spread":0.287841835708425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}