{"id":"W4407780836","doi":"10.1021/jacs.4c15534","title":"Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Hong Kong University of Science and Technology; Basic and Applied Basic Research Foundation of Guangdong Province; Research Grants Council, University Grants Committee; Science, Technology and Innovation Commission of Shenzhen Municipality; Innovation and Technology Commission; National Natural Science Foundation of China","keywords":"Sting; Cancer research; Photothermal therapy; Immunotherapy; Chemistry; Cancer immunotherapy; Abscopal effect; Breast cancer; Stimulator of interferon genes; Triple-negative breast cancer; Immunogenic cell death; Tumor microenvironment; Cancer; Agonist; Immune system; Pharmacology; Medicine; Immunology; Internal medicine; Nanotechnology; Receptor; Innate immune system; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930004,0.0001978224,0.0003863373,0.00002552603,0.0001008582,0.00005269697,0.0002442191,0.00006710282,0.000008503104],"category_scores_gemma":[0.00006739716,0.0001437862,0.0004309469,0.0002238538,0.0001743275,0.0001786368,0.00002828703,0.0002715646,6.178819e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005576609,"about_ca_system_score_gemma":0.0001360951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008472327,"about_ca_topic_score_gemma":0.000001345779,"domain_scores_codex":[0.9990097,0.00001165227,0.0004152321,0.0001300503,0.0001601997,0.0002732157],"domain_scores_gemma":[0.9989381,0.0002900578,0.0003858227,0.0001147511,0.0002207059,0.00005059295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000502899,0.00002480383,0.0001427741,0.0001247761,0.0005221139,1.060035e-7,0.0004958386,0.004246864,0.9799593,0.00000473538,0.003321083,0.01065471],"study_design_scores_gemma":[0.003573716,0.00008305756,0.001591033,0.0001741283,0.0001081568,0.00001001916,0.0007780981,0.06084197,0.9318166,0.0002733725,0.0005332216,0.0002165852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9281073,0.0001683314,0.06956479,0.0008847679,0.0003166862,0.0007429897,0.0001619181,0.00003444936,0.00001875809],"genre_scores_gemma":[0.9776781,0.0002632416,0.02088482,0.0005998168,0.0003595001,0.0001204069,0.000002155014,0.0000525266,0.00003947514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05659511,"threshold_uncertainty_score":0.5863432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861333453631768,"score_gpt":0.2816014854552807,"score_spread":0.262988150918963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}