{"id":"W4407786230","doi":"10.2174/1570159x23666250127161855","title":"Quantification of [<sup>11</sup>C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations","year":2025,"lang":"en","type":"article","venue":"Current Neuropharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital; McMaster University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Health Canada; Government of Canada; Fondation Brain Canada; Alzheimer's Association","keywords":"Binding potential; Cerebellum; Human brain; Metabotropic glutamate receptor 5; In vivo; Positron emission tomography; Chemistry; Nuclear medicine; Nuclear magnetic resonance; Neuroscience; Glutamate receptor; Medicine; Metabotropic glutamate receptor; Biology; Receptor; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006202932,0.0007878494,0.0005431062,0.0007976172,0.000419875,0.001464042,0.001703995,0.001242753,0.001466779],"category_scores_gemma":[0.006405509,0.0006949645,0.0003063491,0.0008303789,0.001418527,0.0007443808,0.0004111187,0.0003836707,0.0006680253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001089006,"about_ca_system_score_gemma":0.0007004036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00748499,"about_ca_topic_score_gemma":0.008273867,"domain_scores_codex":[0.9973866,0.001088406,0.0002063248,0.0006124874,0.0006103952,0.00009573823],"domain_scores_gemma":[0.9968119,0.001377712,0.0005599943,0.0006975649,0.0005010494,0.00005168778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001422194,0.00005024306,0.02418142,0.001879019,0.0004417851,0.0007578211,0.000429166,0.004596786,0.8790595,0.001992885,0.001401669,0.08378755],"study_design_scores_gemma":[0.00008083514,0.001273436,0.1591406,0.000453031,0.0009861363,0.009698959,0.0004827911,0.03211745,0.7749015,0.003349731,0.01738661,0.0001288991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.539984,0.03903725,0.4095926,0.001176176,0.0001813925,0.0004626623,0.001749698,0.001607046,0.006209243],"genre_scores_gemma":[0.8946512,0.005687556,0.09603104,0.0004809301,0.00004798688,0.0004986122,0.0009020236,0.0003133333,0.001387265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00748499,"threshold_uncertainty_score":0.03280467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2923688720310469,"score_gpt":0.4620845218446374,"score_spread":0.1697156498135904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}