{"id":"W4407799686","doi":"10.1097/qai.0000000000003648","title":"Leronlimab Treatment for Multidrug-Resistant HIV-1 (OPTIMIZE): A Randomized, Double-Blind, Placebo-Controlled Trial","year":2025,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cytodiagnostics (Canada)","funders":"","keywords":"Placebo; Medicine; Adverse effect; Clinical endpoint; Internal medicine; Randomized controlled trial; Viral load; Human immunodeficiency virus (HIV); Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002640689,0.001292486,0.003084274,0.000443903,0.0004871164,0.001080765,0.0008377435,0.00226981,0.00696398],"category_scores_gemma":[0.001913256,0.0006619125,0.001543711,0.0003779482,0.001095987,0.0009657518,0.000331759,0.001646505,0.0007413137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005053992,"about_ca_system_score_gemma":0.000996238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004921289,"about_ca_topic_score_gemma":0.001155043,"domain_scores_codex":[0.9990189,0.0005832106,0.00007223908,0.0001683618,0.00006594847,0.0000912908],"domain_scores_gemma":[0.9992669,0.000242469,0.0002048806,0.00006161554,0.00005981531,0.0001642606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9823864,0.003499043,0.0002978538,0.001183631,0.0006734474,0.00002477535,0.00002918645,0.0001143372,0.00148696,0.00006553152,0.0004685782,0.00977027],"study_design_scores_gemma":[0.9754749,0.02291075,0.0006274673,0.00004557679,0.0002818651,0.00001650411,0.000007475654,0.0001121666,0.0001530336,0.00003105406,0.0003327895,0.000006411095],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603994,0.01788587,0.00155638,0.001107714,0.00117128,0.01306209,0.001290572,0.0003171959,0.003209308],"genre_scores_gemma":[0.9630127,0.009162108,0.003564341,0.002466522,0.001220638,0.01532283,0.001002619,0.00004189178,0.004206226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00696398,"threshold_uncertainty_score":0.02329677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02983828911822841,"score_gpt":0.3133912342526641,"score_spread":0.2835529451344357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}