{"id":"W4407803354","doi":"10.1158/2767-9764.crc-24-0638","title":"Safety and Antitumor Activity of a Novel aCD25 Treg Depleter RG6292 as a Single Agent and in Combination with Atezolizumab in Patients with Solid Tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); BC Cancer Agency; Princess Margaret Cancer Centre; University Health Network; Ottawa Hospital","funders":"Genentech; Symphogen; BeiGene; AstraZeneca; Pfizer","keywords":"Atezolizumab; Medicine; Solid tumor; Cancer research; Oncology; Internal medicine; Cancer; Immunotherapy; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003299825,0.0001143907,0.0002813971,0.0004105918,0.0002283649,0.00001558945,0.0003508545,0.0001005958,0.00001715499],"category_scores_gemma":[0.00007903349,0.00009414137,0.00001367026,0.0005519832,0.001113555,0.000102697,0.0004382039,0.0005389687,0.000002385408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000191668,"about_ca_system_score_gemma":0.0002527811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002461002,"about_ca_topic_score_gemma":0.006113889,"domain_scores_codex":[0.9987581,0.0004144842,0.0002312967,0.0002381387,0.00006084574,0.0002971415],"domain_scores_gemma":[0.9987463,0.0003229726,0.00008769278,0.0006259214,0.0001992521,0.00001790363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006605629,0.004878626,0.2395533,0.0001493042,0.0002559059,0.000003372713,0.002250789,0.000025518,0.7123233,0.003850597,0.0001006195,0.03000306],"study_design_scores_gemma":[0.01796152,0.001351439,0.916676,0.0009776378,0.00003125421,0.000008729947,0.0006798693,0.0001025592,0.05895083,0.000252082,0.002755859,0.0002521927],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946778,0.002326771,0.00005114515,0.001353119,0.00002091618,0.000599953,0.00003473557,0.00001092176,0.0009245845],"genre_scores_gemma":[0.9983147,0.0009918236,0.00008078959,0.00002998714,9.135954e-7,0.0001262945,0.00005004547,0.0000094249,0.0003960367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6771228,"threshold_uncertainty_score":0.4102939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04126457459301598,"score_gpt":0.3349189605435808,"score_spread":0.2936543859505649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}