{"id":"W4407808735","doi":"10.1002/adfm.202419562","title":"Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing","year":2025,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; McGill University; Shriners Hospitals for Children; Institut de Recherche Clinique De Montréal; Canadian Institutes of Health Research; McGill University Health Centre; Canada Research Chairs","keywords":"Mesenchymal stem cell; Materials science; Extracellular vesicles; Vesicle; Bone healing; Nanotechnology; Cell biology; Biomedical engineering; Medicine; Biology; Membrane; Biochemistry; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761712,0.0002589471,0.0001629878,0.0002612454,0.00009198012,0.0003422393,0.0001433252,0.0003739924,0.0008494488],"category_scores_gemma":[0.0001144348,0.0001004001,0.0002358671,0.0001127715,0.0001506365,0.0002603683,0.0003056067,0.000267542,0.000349948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068262,"about_ca_system_score_gemma":0.0001547952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001388342,"about_ca_topic_score_gemma":0.0002253029,"domain_scores_codex":[0.999892,0.00002284038,0.000009508148,0.00001671283,0.00004107063,0.00001773225],"domain_scores_gemma":[0.9999559,0.000008858014,0.00001261753,0.000003193495,0.00000976372,0.000009636544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000804037,0.00002551643,0.0000996528,0.0002365873,0.00001227006,0.00009389724,0.00002252481,0.0004843505,0.9876235,0.001422443,0.0002884958,0.009610489],"study_design_scores_gemma":[0.00001311111,0.0001538623,0.0004137067,0.00002024388,0.00001994136,0.0001192574,0.00002265222,0.001868429,0.9845293,0.0002954364,0.01253591,0.000008119779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8843194,0.04283521,0.0592062,0.0006782235,0.0004962108,0.0002510375,0.0008221745,0.0005289945,0.01086252],"genre_scores_gemma":[0.9785139,0.008113375,0.009463436,0.0001386341,0.0000471134,0.00009801368,0.0002185127,0.00003704913,0.003369957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008494488,"threshold_uncertainty_score":0.002841711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013362020263734,"score_gpt":0.2531883708954488,"score_spread":0.2430547506928115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}