{"id":"W4407819338","doi":"10.1016/j.clcc.2025.02.003","title":"A Phase Two, Single-Arm, Open-Label Study With Dostarlimab Monotherapy in Participants With Untreated Stage II/III dMMR/MSI-H Locally Advanced Rectal Cancer (AZUR-1)","year":2025,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"GlaxoSmithKline","keywords":"Medicine; Colorectal cancer; Stage (stratigraphy); Oncology; Internal medicine; Open label; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009774881,0.0006669657,0.001643262,0.0002469818,0.0002721845,0.0001228612,0.0005280824,0.0002502211,0.001001494],"category_scores_gemma":[0.0001101765,0.000471175,0.0001356009,0.001887779,0.0006480651,0.0003476952,0.0002066825,0.0008632175,0.000003956906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001076638,"about_ca_system_score_gemma":0.002492452,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007354076,"about_ca_topic_score_gemma":0.06424794,"domain_scores_codex":[0.9952062,0.0003513804,0.001435936,0.001402386,0.0005584178,0.001045731],"domain_scores_gemma":[0.9976915,0.0004200744,0.0004617438,0.0006608124,0.0004047945,0.0003611085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6027512,0.04660546,0.151117,0.00008422348,0.002400632,0.0005598812,0.001278226,0.0001389552,0.01377829,0.00001259167,0.0007224551,0.180551],"study_design_scores_gemma":[0.7077603,0.1786144,0.06921323,0.003851065,0.001332315,0.00002227016,0.002930825,0.001872641,0.01785443,0.00002990106,0.01481582,0.00170282],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875181,0.002905818,0.00006383228,0.001769361,0.0005700747,0.00544908,0.0001279331,0.0001552706,0.001440514],"genre_scores_gemma":[0.9889957,0.001062183,0.0003959076,0.003354148,0.0001361997,0.00240547,0.00003078211,0.0001026944,0.003516869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1788482,"threshold_uncertainty_score":0.9999117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0939701663074966,"score_gpt":0.4541728769110935,"score_spread":0.3602027106035969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}