{"id":"W4407819338","doi":"10.1016/j.clcc.2025.02.003","title":"A Phase Two, Single-Arm, Open-Label Study With Dostarlimab Monotherapy in Participants With Untreated Stage II/III dMMR/MSI-H Locally Advanced Rectal Cancer (AZUR-1)","year":2025,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"GlaxoSmithKline","keywords":"Medicine; Colorectal cancer; Stage (stratigraphy); Oncology; Internal medicine; Open label; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003286488,0.0018817,0.002334613,0.0004335625,0.0007649518,0.0008911777,0.001018917,0.001869969,0.008878616],"category_scores_gemma":[0.001504068,0.000800185,0.00145123,0.0002844748,0.001038829,0.001345914,0.0004787582,0.0032242,0.001951618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000672942,"about_ca_system_score_gemma":0.002081786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969242,"about_ca_topic_score_gemma":0.001713483,"domain_scores_codex":[0.9991541,0.0004298375,0.00004181825,0.0001551283,0.00007581441,0.0001432225],"domain_scores_gemma":[0.9989442,0.0001469984,0.0001991511,0.00008809162,0.0001056071,0.0005159894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.820083,0.1225627,0.004048903,0.0007474406,0.0008479443,0.0001244899,0.000265682,0.000413399,0.02010656,0.0001650708,0.002445754,0.02818901],"study_design_scores_gemma":[0.5835345,0.4074576,0.005867487,0.0000220003,0.000256047,0.00006638753,0.0000457262,0.0003210754,0.0008681794,0.0001315059,0.00141255,0.00001692804],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810733,0.001385338,0.0008174568,0.0005240999,0.0002640687,0.01206787,0.001836822,0.0001291933,0.001901835],"genre_scores_gemma":[0.9672996,0.001111493,0.003531928,0.001845818,0.0004397281,0.01864684,0.002155887,0.00003880959,0.004929841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008878616,"threshold_uncertainty_score":0.02970195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0939701663074966,"score_gpt":0.4541728769110935,"score_spread":0.3602027106035969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}