{"id":"W4407821003","doi":"10.1002/pbc.31626","title":"Prolonged Hypogammaglobulinemia in a Child With Down Syndrome After Treatment of Acute Lymphoblastic Leukemia With Immunochemotherapy Including Blinatumomab","year":2025,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Blinatumomab; Hypogammaglobulinemia; Lymphoblastic Leukemia; Pediatrics; Leukemia; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146665,0.001305266,0.001042269,0.001207212,0.001615507,0.0005992311,0.0007571601,0.002374022,0.0009551093],"category_scores_gemma":[0.001988529,0.0005990715,0.0007607199,0.001015358,0.001060384,0.0009604014,0.0006271373,0.003061475,0.0002284335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00137196,"about_ca_system_score_gemma":0.000717002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004821812,"about_ca_topic_score_gemma":0.006023093,"domain_scores_codex":[0.9995958,0.00008550875,0.00004117399,0.00009241804,0.00007007211,0.0001149617],"domain_scores_gemma":[0.9991366,0.0002656922,0.0001677678,0.00003441141,0.00005164533,0.0003437847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001965818,0.00007584354,0.03582698,0.00004944255,0.00002282685,0.9591859,0.0003963948,0.0001243703,0.002019514,0.0001217853,0.0003371176,0.001643288],"study_design_scores_gemma":[0.00004187143,0.0008538358,0.07571476,0.0000419773,0.00007505062,0.9202747,0.0003024949,0.0004789121,0.001057363,0.0001307445,0.001004907,0.00002332853],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990681,0.00239061,0.0009745974,0.002435316,0.0001675621,0.0001195284,0.0001889231,0.000106391,0.002936102],"genre_scores_gemma":[0.9973224,0.0009363978,0.0004333219,0.0006405861,0.0001831491,0.00001739245,0.00009936064,0.00001059095,0.0003569627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004821812,"threshold_uncertainty_score":0.009954333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004846125879604169,"score_gpt":0.2146940144112817,"score_spread":0.2098478885316775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}