{"id":"W4407821430","doi":"10.1101/2025.02.21.25321539","title":"First Use of Phage Therapy in Canada for the Treatment of a Life-Threatening, Multidrug-Resistant <i>Staphylococcus epidermidis</i> Periprosthetic Joint Infection: An N-of-1 Trial","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Orthopedic Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Periprosthetic; Staphylococcus epidermidis; Joint infections; Medicine; Multiple drug resistance; Staphylococcus aureus; Microbiology; Virology; Drug resistance; Biology; Surgery; Arthroplasty; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000745988,0.0004345926,0.0006910895,0.0002035306,0.001007097,0.0008273004,0.0003740359,0.001186375,0.002268592],"category_scores_gemma":[0.0009074204,0.0001405785,0.0007065402,0.0002989587,0.0005734245,0.0001957727,0.0002771801,0.001314505,0.0002337548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00446279,"about_ca_system_score_gemma":0.009338467,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.2220865,"about_ca_topic_score_gemma":0.4845093,"domain_scores_codex":[0.9995484,0.0001286241,0.00001682217,0.00004081572,0.0001088542,0.0001564665],"domain_scores_gemma":[0.9993029,0.00006771777,0.00008055378,0.00002372112,0.0001544416,0.0003707884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2953018,0.03229594,0.03982036,0.002502583,0.002865513,0.001112325,0.0009038416,0.002291244,0.02971296,0.001900972,0.03518987,0.5561026],"study_design_scores_gemma":[0.2465581,0.4438193,0.1598257,0.00136607,0.003293448,0.001047849,0.0008396005,0.002891961,0.008501249,0.0009842728,0.1307114,0.0001611624],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439749,0.02581621,0.001270044,0.007215661,0.0006326734,0.003781638,0.002430578,0.0001041956,0.01477428],"genre_scores_gemma":[0.9763278,0.009972199,0.001862209,0.003878286,0.0002428508,0.0008550299,0.00100903,0.00002361868,0.005828771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7779136,"threshold_uncertainty_score":0.4415876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0653728434123796,"score_gpt":0.299871710758298,"score_spread":0.2344988673459184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}