{"id":"W4407828113","doi":"10.1200/po-24-00631","title":"Clinical Effectiveness and Cost-Effectiveness of Multigene Panel Sequencing in Advanced Melanoma: A Population-Level Real-World Target Trial Emulation","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fraser Health; Canada's Michael Smith Genome Sciences Centre; Queen's University; University of British Columbia; Simon Fraser University","funders":"","keywords":"Medicine; Hazard ratio; Proportional hazards model; Oncology; Internal medicine; Population; Censoring (clinical trials); Survival analysis; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05156066,0.001117005,0.001361354,0.0006617416,0.0006088263,0.001576292,0.001658941,0.001694967,0.003398665],"category_scores_gemma":[0.07048758,0.0007320825,0.002828714,0.00085582,0.001666881,0.0014061,0.001342084,0.001845773,0.000434086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004688466,"about_ca_system_score_gemma":0.003003575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006973282,"about_ca_topic_score_gemma":0.005031836,"domain_scores_codex":[0.9557475,0.03919233,0.001006041,0.002235695,0.001040706,0.0007778478],"domain_scores_gemma":[0.9505063,0.03345577,0.00811891,0.005082259,0.001797491,0.001039147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3352753,0.02829972,0.2297987,0.002669636,0.02515681,0.0007906303,0.001258418,0.2510538,0.004276568,0.01419426,0.01184252,0.09538367],"study_design_scores_gemma":[0.1291287,0.1727795,0.1974279,0.000771268,0.01679522,0.001074779,0.0009918192,0.4347373,0.009382333,0.02243031,0.0139381,0.0005427257],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755194,0.0006948234,0.01127303,0.0009238853,0.00009422973,0.005802426,0.003620476,0.00007231525,0.001999506],"genre_scores_gemma":[0.9865984,0.0001246204,0.006620455,0.0003904173,0.00005065681,0.00444134,0.001296655,0.00001559677,0.0004618059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05156066,"threshold_uncertainty_score":0.2726821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09579530884220487,"score_gpt":0.4304783455375418,"score_spread":0.3346830366953369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}