{"id":"W4407828689","doi":"10.1111/pde.15840","title":"Efficacy and Safety of Once‐Daily Roflumilast Cream 0.05% in Pediatric Patients Aged 2–5 Years With Mild‐to‐Moderate Atopic Dermatitis ( <scp>INTEGUMENT</scp> ‐ <scp>PED</scp> ): A Phase 3 Randomized Controlled Trial","year":2025,"lang":"en","type":"article","venue":"Pediatric Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Calgary","funders":"","keywords":"Medicine; Roflumilast; Eczema Area and Severity Index; Tolerability; Atopic dermatitis; Adverse effect; Clinical endpoint; Internal medicine; Randomized controlled trial; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001204,0.0006361036,0.001671676,0.000234604,0.0002867521,0.0005178045,0.000502256,0.0009537408,0.002346584],"category_scores_gemma":[0.000999886,0.000375962,0.001365692,0.0002553424,0.0003999906,0.0004916469,0.0001989793,0.001409075,0.0003498223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005884029,"about_ca_system_score_gemma":0.001007294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007173246,"about_ca_topic_score_gemma":0.001788244,"domain_scores_codex":[0.9995036,0.0002384681,0.00005285177,0.00007856423,0.00006353109,0.0000629024],"domain_scores_gemma":[0.9992788,0.0002035261,0.0002650123,0.00002865861,0.00004923763,0.0001747564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8493271,0.02531514,0.02694087,0.002884086,0.002621652,0.0004988869,0.000307552,0.0006580303,0.01556027,0.0001258982,0.001873969,0.07388662],"study_design_scores_gemma":[0.6020699,0.3295898,0.06086721,0.0001680888,0.001461667,0.0005935584,0.0001014567,0.0006815884,0.002381562,0.00005625572,0.00200249,0.00002645748],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938655,0.004199603,0.0001452071,0.0001135699,0.00005348249,0.0007851056,0.0002905496,0.00002331769,0.0005236773],"genre_scores_gemma":[0.9950908,0.002186871,0.0005038127,0.0003343296,0.00009915147,0.0009777036,0.0004553922,0.000006476484,0.0003454702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002346584,"threshold_uncertainty_score":0.007850051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005885663790117364,"score_gpt":0.2571696805026026,"score_spread":0.2512840167124853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}