{"id":"W4407828689","doi":"10.1111/pde.15840","title":"Efficacy and Safety of Once‐Daily Roflumilast Cream 0.05% in Pediatric Patients Aged 2–5 Years With Mild‐to‐Moderate Atopic Dermatitis ( <scp>INTEGUMENT</scp> ‐ <scp>PED</scp> ): A Phase 3 Randomized Controlled Trial","year":2025,"lang":"en","type":"article","venue":"Pediatric Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Calgary","funders":"","keywords":"Medicine; Roflumilast; Eczema Area and Severity Index; Tolerability; Atopic dermatitis; Adverse effect; Clinical endpoint; Internal medicine; Randomized controlled trial; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006083641,0.0006499621,0.004055962,0.001657128,0.0001716599,0.00004623845,0.0002919743,0.000514565,0.00002508026],"category_scores_gemma":[0.006681771,0.0005422722,0.000429247,0.001315385,0.0003766109,0.0001897747,0.0001823544,0.0006141965,0.00004308643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008298452,"about_ca_system_score_gemma":0.0007413276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003510954,"about_ca_topic_score_gemma":0.00003197557,"domain_scores_codex":[0.994209,0.001290253,0.002204581,0.0008349065,0.000522702,0.0009385883],"domain_scores_gemma":[0.9902242,0.007651162,0.0007873362,0.0005576374,0.0003087429,0.0004709257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4442126,0.006848626,0.468507,0.001277313,0.001116084,0.001413718,0.00245365,0.0000411093,0.000006739836,0.000209524,0.07337189,0.0005417622],"study_design_scores_gemma":[0.860752,0.0005309631,0.1341996,0.00008630557,0.002708582,0.0001596786,0.0001760926,0.000263124,0.00007866324,0.0001399184,0.0007801531,0.0001249312],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839044,0.004251535,0.0003234641,0.0004064903,0.0007728133,0.007808624,0.0000576429,0.0001250823,0.002349943],"genre_scores_gemma":[0.9941849,0.0022679,0.0002924331,0.001208443,0.0001932022,0.0009726528,0.0001452404,0.00005228325,0.0006829595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4165394,"threshold_uncertainty_score":0.9997029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005885663790117364,"score_gpt":0.2571696805026026,"score_spread":0.2512840167124853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}