{"id":"W4407837517","doi":"10.1158/1055-9965.epi-24-0970","title":"Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study","year":2025,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Junta de Castilla y León; Conseil Régional des Pays de la Loire; Xunta de Galicia; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; Mutuelle Générale de l'Education Nationale; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Institut National Du Cancer; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; University of Pittsburgh; Stockholms Läns Landsting; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; Imperial College London; Generalitat de Catalunya; Food Standards Agency; University of South Florida; Swedish Cancer Foundation; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; National Institute of Allergy and Infectious Diseases; Victorian Cancer Agency; University of Cambridge; Association Anne de Bretagne Genetique; Ligue Contre le Cancer; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Biobanco Vasco; Fred Hutchinson Cancer Research Center; Moffitt Cancer Center; Pelotonia; Brigham and Women's Hospital; Emory University; Damon Runyon Cancer Research Foundation; American Cancer Society; Memorial Sloan-Kettering Cancer Center; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Fondation ARC pour la Recherche sur le Cancer; U.S. Department of Health and Human Services","keywords":"Medicine; Hay fever; Mendelian randomization; Colorectal cancer; Internal medicine; Odds ratio; Allergy; Asthma; Cancer; Genome-wide association study; Oncology; Immunology; Single-nucleotide polymorphism; Genotype; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01180233,0.0007652175,0.0008296339,0.00084429,0.000476564,0.0006293601,0.00083993,0.0008369911,0.002043104],"category_scores_gemma":[0.02858034,0.0004631238,0.001428833,0.000961457,0.0008015499,0.0003393723,0.0004998927,0.0005593315,0.0001653449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003953207,"about_ca_system_score_gemma":0.0006033714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003652815,"about_ca_topic_score_gemma":0.002004656,"domain_scores_codex":[0.9864031,0.009812768,0.0006031868,0.0021432,0.0007284876,0.0003092428],"domain_scores_gemma":[0.9814788,0.009891359,0.003301989,0.004402268,0.0004683402,0.0004571647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01537177,0.0004898293,0.9363413,0.0002087695,0.008616594,0.002554912,0.0006603177,0.003437902,0.006695549,0.004661717,0.001213279,0.01974797],"study_design_scores_gemma":[0.004561522,0.006759762,0.8846925,0.0001143819,0.008425222,0.01040808,0.0003057911,0.06974036,0.002295879,0.00853393,0.003940495,0.0002220187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819329,0.0005245341,0.01619649,0.000179961,0.00003366669,0.0001689905,0.0003766851,0.00009563766,0.0004910565],"genre_scores_gemma":[0.9944156,0.00009210734,0.004973994,0.00006230131,0.00001921287,0.00009229226,0.0001553802,0.00001720051,0.0001719464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01180233,"threshold_uncertainty_score":0.06241745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00960232828376946,"score_gpt":0.3079302807519269,"score_spread":0.2983279524681575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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