{"id":"W4407838968","doi":"10.1093/biolre/ioaf035","title":"Disruption of oocyte SUMOylation impacts critical regulatory processes during folliculogenesis in mice","year":2025,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Biology; SUMO protein; Folliculogenesis; Oocyte; Cell biology; Conditional gene knockout; Wnt signaling pathway; Proteomics; Transcriptome; Ovarian follicle; Genetics; Phenotype; Ovary; Signal transduction; Ubiquitin; Gene expression; Gene; Embryo; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939705,0.0003993661,0.0003447582,0.0006559457,0.0002512948,0.000450157,0.0003028717,0.0004323751,0.001484491],"category_scores_gemma":[0.0001963207,0.0003965894,0.0003785598,0.0002120365,0.0004855202,0.0003054567,0.0003258217,0.0007722603,0.0003846786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004475105,"about_ca_system_score_gemma":0.0002689614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004643223,"about_ca_topic_score_gemma":0.0007415698,"domain_scores_codex":[0.9997491,0.00002315228,0.00002678698,0.00008593924,0.00005765546,0.00005723199],"domain_scores_gemma":[0.999728,0.00002632042,0.0001284123,0.00001792116,0.00001529592,0.00008406542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001965113,0.00002125786,0.0002596749,0.00001307348,0.000004561453,0.00005962551,0.00001515062,0.00003003161,0.9986519,0.0001089415,0.00001873812,0.0006205126],"study_design_scores_gemma":[0.00007302767,0.0003984946,0.02408105,0.00001610775,0.00003683727,0.0005568857,0.00008148006,0.0009181477,0.9712554,0.0002166402,0.002352953,0.00001286809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946825,0.0007959663,0.002693448,0.0001246479,0.00003198256,0.00003090269,0.000637231,0.0001227877,0.0008805722],"genre_scores_gemma":[0.9915902,0.0007487371,0.002283535,0.0001155491,0.00001416201,0.00009065561,0.0005498716,0.0001219172,0.004485401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484491,"threshold_uncertainty_score":0.00496608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167370437609353,"score_gpt":0.2879036837605232,"score_spread":0.2762299793844297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}