{"id":"W4407839638","doi":"10.1167/iovs.66.2.55","title":"Elevated Plasma Complement Factors in <i>CRB1</i>-Associated Inherited Retinal Dystrophies","year":2025,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Complement (music); Retinal; Retinal degeneration; Ophthalmology; Medicine; Biology; Genetics; Phenotype; Complementation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005714161,0.0002616403,0.0002570259,0.0002953162,0.0002842041,0.0000482136,0.0004957022,0.0001617937,0.00004472571],"category_scores_gemma":[0.0009876435,0.0002439699,0.00005154303,0.00155529,0.002443331,0.00001828331,0.000339432,0.0001937261,0.000008196732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001061013,"about_ca_system_score_gemma":0.000554101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000160125,"about_ca_topic_score_gemma":0.0000530777,"domain_scores_codex":[0.9978528,0.0001999633,0.0003897998,0.0006881633,0.0002772133,0.0005920782],"domain_scores_gemma":[0.9992755,0.00005021958,0.0001476239,0.0001829915,0.0002092121,0.0001344578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004963608,0.00008016443,0.3627974,0.000005272685,0.00001794101,0.00002035381,0.0001283135,0.00001425308,0.6366178,0.0001022333,0.0001424088,0.00002428354],"study_design_scores_gemma":[0.0005440163,0.0003573269,0.5568364,0.00004334585,0.000005952527,0.000009329083,0.0004443704,0.0001032712,0.4403334,0.0008911154,0.0002248806,0.0002065902],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960887,0.00005159438,0.000004495546,0.0003071153,0.0002049408,0.0002852244,0.000009874187,0.0000199954,0.003027992],"genre_scores_gemma":[0.9987502,0.00001058623,0.0003384914,0.0002178645,0.00001163294,0.00003468048,0.0001197963,0.000009962108,0.0005067763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1962843,"threshold_uncertainty_score":0.9948802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02616985909450098,"score_gpt":0.3190592545040511,"score_spread":0.2928893954095502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}