{"id":"W4407839638","doi":"10.1167/iovs.66.2.55","title":"Elevated Plasma Complement Factors in <i>CRB1</i>-Associated Inherited Retinal Dystrophies","year":2025,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Complement (music); Retinal; Retinal degeneration; Ophthalmology; Medicine; Biology; Genetics; Phenotype; Complementation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003041638,0.0006902076,0.0003492534,0.001040714,0.0003568289,0.0003566356,0.0002143512,0.0004698197,0.001454359],"category_scores_gemma":[0.0007140035,0.0001641009,0.0002320468,0.000615023,0.0003067448,0.000151508,0.0002928684,0.0002939129,0.0001839953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266752,"about_ca_system_score_gemma":0.0001421171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002454816,"about_ca_topic_score_gemma":0.001308825,"domain_scores_codex":[0.9997708,0.0000343414,0.00002749382,0.00009630842,0.00004331355,0.0000277729],"domain_scores_gemma":[0.9996761,0.00005752658,0.0001802859,0.00001274319,0.00003401232,0.00003937669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001565445,0.00008714083,0.936316,0.0001105002,0.0001600878,0.001657028,0.0002654316,0.0001714123,0.0516674,0.00005890707,0.0003202701,0.007620341],"study_design_scores_gemma":[0.0000361524,0.000308637,0.9909819,0.00001959573,0.00008038856,0.004243493,0.00008848589,0.0002243597,0.003542731,0.00004242863,0.0004259057,0.000005957866],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999119,0.0003783139,0.0001295574,0.00002166573,0.000003279964,0.000006557454,0.000162345,0.000006715559,0.0001725198],"genre_scores_gemma":[0.9992527,0.0001204997,0.0002607152,0.00004189983,0.00000710932,0.000005107799,0.0001934591,0.000003363606,0.0001150995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002454816,"threshold_uncertainty_score":0.004881084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02616985909450098,"score_gpt":0.3190592545040511,"score_spread":0.2928893954095502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}