{"id":"W4407840028","doi":"10.7554/elife.105722","title":"Structure and Cl- Conductance Properties of the Open State of Human CFTR","year":2025,"lang":"en","type":"preprint","venue":"eLife","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Hospital for Sick Children","keywords":"Cystic fibrosis transmembrane conductance regulator; Gating; Conductance; Lipid bilayer; Chemistry; Biophysics; Ion channel; Molecular dynamics; Transmembrane protein; Permeation; Thermal conduction; Bilayer; Chemical physics; Membrane; Materials science; Computational chemistry; Biochemistry; Physics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053162,0.0001573018,0.0001460521,0.0001026208,0.0002457673,0.0001903349,0.0001823498,0.0002754529,0.001244123],"category_scores_gemma":[0.0002814536,0.00009041686,0.0001557313,0.00009688731,0.0002715005,0.0001597335,0.000114336,0.0002886158,0.000134746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002968892,"about_ca_system_score_gemma":0.0001683799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002167877,"about_ca_topic_score_gemma":0.001078749,"domain_scores_codex":[0.9999433,0.000008828662,0.000002910271,0.00001863409,0.00001481018,0.00001164063],"domain_scores_gemma":[0.999911,0.00003596916,0.00001524946,0.000008232233,0.00001299877,0.0000166105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008427994,0.0001957267,0.005033739,0.000109414,0.00006333841,0.000619242,0.0004237999,0.02978348,0.9555002,0.002242815,0.0006782308,0.004507155],"study_design_scores_gemma":[0.0004030623,0.002656352,0.04354803,0.00006464199,0.0001061115,0.0010317,0.0005606186,0.3661566,0.5772387,0.003061201,0.005031122,0.0001418831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984673,0.0001356987,0.0008195425,0.00002383816,0.000005933341,0.000003915044,0.0001434848,0.00001925173,0.0003809453],"genre_scores_gemma":[0.9989132,0.00005329212,0.0005144607,0.000008658646,0.000001523475,0.000004080338,0.0003035218,0.000006824697,0.0001945065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002167877,"threshold_uncertainty_score":0.004310548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05310169767250617,"score_gpt":0.3650036536089933,"score_spread":0.3119019559364872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}