{"id":"W4407863613","doi":"10.1158/2326-6074.io2025-a015","title":"Abstract A015: GPNMB CAR T cells target both Glioblastoma and its immunosuppressive niche to relieve immune evasion","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; McMaster University","funders":"","keywords":"Evasion (ethics); Glioblastoma; Niche; Immune system; Immunotherapy; Immunology; Cancer immunotherapy; Biology; Cancer research; Medicine; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046615,0.0002239809,0.0002108418,0.0002964126,0.0002111066,0.0004415873,0.0002017534,0.0003188854,0.00768352],"category_scores_gemma":[0.00008963556,0.00009658123,0.0001814953,0.0001858758,0.0002235284,0.0002148357,0.0002147171,0.0005139972,0.001270128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889858,"about_ca_system_score_gemma":0.0003723648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006845027,"about_ca_topic_score_gemma":0.0009865754,"domain_scores_codex":[0.9999194,0.000007750145,0.00000495527,0.00001935177,0.00002935566,0.00001914055],"domain_scores_gemma":[0.999958,0.00000474083,0.000008003803,0.000002986738,0.0000113027,0.00001494859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001869149,0.00004826197,0.0008972082,0.00008443929,0.000009442977,0.0001624846,0.00003185841,0.0001314264,0.9868228,0.0004620276,0.001263928,0.009899106],"study_design_scores_gemma":[0.00005954238,0.0009738352,0.01315818,0.00002636486,0.00004322664,0.001599647,0.0001853909,0.002154692,0.9545148,0.0005375773,0.02673407,0.00001273204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776289,0.003669922,0.006739311,0.001193848,0.0002713743,0.0001228179,0.000989489,0.0004136709,0.008970781],"genre_scores_gemma":[0.971374,0.002019828,0.005182636,0.0005217519,0.0000743956,0.00008438814,0.0008290629,0.0000502486,0.01986381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00768352,"threshold_uncertainty_score":0.02570391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03854279659123545,"score_gpt":0.391782521747186,"score_spread":0.3532397251559506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}