{"id":"W4407864998","doi":"10.1101/2025.02.21.639524","title":"Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Toronto Centre for Phenogenomics; Université Laval","funders":"","keywords":"Reprogramming; Somatic cell; RNA; Biology; Computational biology; Non-coding RNA; Gene isoform; Genetics; Cell biology; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003850563,0.0002067711,0.0001445518,0.000215388,0.0001456117,0.0003978126,0.0001506879,0.0003009462,0.0009524036],"category_scores_gemma":[0.0003398777,0.0001274084,0.0001289316,0.0001724676,0.0002306754,0.0002343216,0.000157489,0.0003439196,0.0004613831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001621056,"about_ca_system_score_gemma":0.0001514203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002220293,"about_ca_topic_score_gemma":0.0005094782,"domain_scores_codex":[0.9998624,0.00002353565,0.000008318018,0.0000442335,0.00004549392,0.00001593686],"domain_scores_gemma":[0.9997332,0.00009384315,0.0000673776,0.00003657567,0.00004349914,0.00002556044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003805289,0.000005999217,0.0008979092,0.00001458895,0.000002612183,0.00003170875,0.00001022661,0.0001245806,0.9966101,0.0001362443,0.00006701197,0.002060959],"study_design_scores_gemma":[0.000006861226,0.00008232345,0.01980744,0.000007826774,0.00001408853,0.0002693496,0.00004517376,0.007333768,0.9690034,0.0008002683,0.002618687,0.00001084958],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535751,0.001362144,0.04035571,0.0002230608,0.00008753467,0.00002247686,0.001000413,0.0004244641,0.002949081],"genre_scores_gemma":[0.9677104,0.0007457399,0.02426112,0.0001622908,0.00003433938,0.00002312539,0.001750474,0.0001254525,0.005187081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009524036,"threshold_uncertainty_score":0.003186047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053398760808335,"score_gpt":0.2458891505183532,"score_spread":0.2353551629102698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}