{"id":"W4407866505","doi":"10.1158/2326-6074.io2025-b016","title":"Abstract B016: Prime-Boost: mRNA Tumor Vaccines in Combination with Oncolytic Virotherapy for Durable Anti-Tumor Immunity","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Virotherapy; Medicine; Immunity; Immunotherapy; Immunology; Virology; Cancer research; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291003,0.0006329951,0.0005832448,0.0003671502,0.0001191839,0.0004503298,0.0002777385,0.0004076046,0.002489545],"category_scores_gemma":[0.0001466353,0.000220732,0.0003302491,0.0002454277,0.0002722724,0.0002600932,0.000240525,0.001143459,0.0007559821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985493,"about_ca_system_score_gemma":0.0004185553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004997615,"about_ca_topic_score_gemma":0.0004256431,"domain_scores_codex":[0.9997965,0.0000314499,0.00001418491,0.00004226747,0.00005948863,0.00005615574],"domain_scores_gemma":[0.999921,0.000014592,0.00001865345,0.00001202755,0.000009291846,0.0000245376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005479162,0.0003615214,0.0001390344,0.0001102687,0.00001190461,0.00004697688,0.00001363843,0.0005409188,0.9872651,0.0003006387,0.000255231,0.01040685],"study_design_scores_gemma":[0.0001339306,0.003782171,0.0007741274,0.00001292065,0.00003656236,0.0001972823,0.000007773478,0.00234702,0.9891101,0.00007710877,0.003512118,0.000008936967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972374,0.003768687,0.01779604,0.0003580298,0.0003419837,0.0002757823,0.0003853879,0.0005752562,0.004124816],"genre_scores_gemma":[0.9803971,0.001243839,0.01256662,0.00009005503,0.0000751371,0.0001401333,0.0003071573,0.00008800752,0.005091983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002489545,"threshold_uncertainty_score":0.008328319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03169217769698976,"score_gpt":0.3801940670028855,"score_spread":0.3485018893058958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}