{"id":"W4407866505","doi":"10.1158/2326-6074.io2025-b016","title":"Abstract B016: Prime-Boost: mRNA Tumor Vaccines in Combination with Oncolytic Virotherapy for Durable Anti-Tumor Immunity","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Virotherapy; Medicine; Immunity; Immunotherapy; Immunology; Virology; Cancer research; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001735763,0.0002506307,0.0003704457,0.0005276307,0.0003742368,0.00006506677,0.0007968894,0.000205164,0.0001369496],"category_scores_gemma":[0.0002246037,0.0002270371,0.00008392404,0.0007775472,0.0004457709,0.00001832229,0.0001859955,0.0007257256,0.00001630615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003149094,"about_ca_system_score_gemma":0.001704961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006870218,"about_ca_topic_score_gemma":0.001954174,"domain_scores_codex":[0.9973545,0.0004290308,0.0003681789,0.00062398,0.0002872465,0.0009370543],"domain_scores_gemma":[0.9980981,0.0002092293,0.00009411706,0.0008398992,0.0006923054,0.00006628809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01272743,0.0004330114,0.009737222,0.00009724519,0.0002724018,0.00001313382,0.00006241329,0.00007545309,0.9632836,0.00008898519,0.0008197293,0.01238939],"study_design_scores_gemma":[0.007123322,0.004163121,0.05523802,0.0001548546,0.000009355444,0.000009125362,0.0002494883,0.0001041397,0.9210271,0.000413491,0.01123178,0.0002761624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985748,0.009603749,0.0001054879,0.001642799,0.0001473794,0.001834653,0.00003288747,0.00002253063,0.0008625094],"genre_scores_gemma":[0.9935413,0.002104669,0.00007253974,0.0002631751,0.00008265584,0.001612355,0.00007981121,0.00005602204,0.00218748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0455008,"threshold_uncertainty_score":0.9258306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03169217769698976,"score_gpt":0.3801940670028855,"score_spread":0.3485018893058958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}