{"id":"W4407866729","doi":"10.1158/2326-6074.io2025-b122","title":"Abstract B122: Genetically engineered Vaccinia Virus expressing MHC-I as a precision medicine cancer vaccine","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Vaccinia; Virology; Genetically engineered; Cancer; Virus; Cancer vaccine; Genetically modified organism; Cancer immunotherapy; Medicine; Major histocompatibility complex; Biology; Immunology; Immunotherapy; Immune system; Recombinant DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273131,0.0003080953,0.0001914052,0.0001483563,0.00009421666,0.0003104107,0.000215121,0.0004592212,0.001527655],"category_scores_gemma":[0.00008950821,0.000108336,0.0001875463,0.0001016791,0.0001154333,0.0001486357,0.000117742,0.0007544276,0.0004622968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003350951,"about_ca_system_score_gemma":0.0001523241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004388248,"about_ca_topic_score_gemma":0.0003038707,"domain_scores_codex":[0.9998804,0.00001655739,0.000008214705,0.00002163915,0.00004250629,0.00003059518],"domain_scores_gemma":[0.9999642,0.000004849556,0.00001099351,0.000003336992,0.000007442432,0.000009158206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009783142,0.00009416596,0.0001614694,0.00003164982,0.00000458634,0.00003064968,0.000005350145,0.0003091322,0.9969252,0.0002496241,0.0001884669,0.001901789],"study_design_scores_gemma":[0.00006178245,0.001797706,0.001212478,0.00001268435,0.00001655347,0.0002581189,0.00001237963,0.003041252,0.9837021,0.00008926009,0.009789253,0.000006379305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825806,0.002638481,0.00918185,0.0003623834,0.0002063624,0.0001835534,0.0005196601,0.0001265312,0.004200535],"genre_scores_gemma":[0.983574,0.0007996257,0.008552413,0.0001432546,0.0000310337,0.00008205865,0.0007681233,0.00002087844,0.006028578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527655,"threshold_uncertainty_score":0.005110562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03941943681818824,"score_gpt":0.4162353845623751,"score_spread":0.3768159477441868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}