{"id":"W4407866729","doi":"10.1158/2326-6074.io2025-b122","title":"Abstract B122: Genetically engineered Vaccinia Virus expressing MHC-I as a precision medicine cancer vaccine","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Vaccinia; Virology; Genetically engineered; Cancer; Virus; Cancer vaccine; Genetically modified organism; Cancer immunotherapy; Medicine; Major histocompatibility complex; Biology; Immunology; Immunotherapy; Immune system; Recombinant DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001591963,0.000370384,0.0004845698,0.0006002758,0.0004093726,0.000063035,0.001252856,0.0005785382,0.002431411],"category_scores_gemma":[0.0007708942,0.0003292945,0.0001205549,0.0008948513,0.0006015431,0.0000129588,0.0006922295,0.001102659,0.00009406456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507542,"about_ca_system_score_gemma":0.001437475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001352929,"about_ca_topic_score_gemma":0.001120686,"domain_scores_codex":[0.995976,0.0005034777,0.0005747764,0.001045072,0.0006370355,0.001263689],"domain_scores_gemma":[0.9972162,0.0002571405,0.00008798454,0.001290578,0.0009480325,0.0002000543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008094894,0.000105651,0.0005406712,0.00005593959,0.0004393953,0.00001815084,0.00009046972,0.0001430258,0.8887417,0.0000550797,0.01449089,0.08722416],"study_design_scores_gemma":[0.003099239,0.002280349,0.009398664,0.000315999,0.00002863446,0.000008280086,0.000140648,0.00009817869,0.9184106,0.0004126267,0.06548852,0.0003182559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8760126,0.1135382,0.0001086662,0.005840718,0.0005095341,0.0007188724,0.00003693683,0.00004369902,0.003190762],"genre_scores_gemma":[0.9561639,0.03672017,0.00007281271,0.0005185604,0.0006461258,0.0008146733,0.00007562462,0.00007873656,0.004909398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0869059,"threshold_uncertainty_score":0.9999159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03941943681818824,"score_gpt":0.4162353845623751,"score_spread":0.3768159477441868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}