{"id":"W4407866806","doi":"10.1158/2326-6074.io2025-a060","title":"Abstract A060: Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Glioblastoma; Glioma; Stem cell; Cancer research; CCL5; Temozolomide; Medicine; Biology; T cell; Immunology; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722098,0.0003103216,0.0003068697,0.0004822152,0.000358793,0.0006672626,0.0002490332,0.0004106101,0.007248658],"category_scores_gemma":[0.0001442201,0.0001342301,0.0003620775,0.0004276143,0.0002046167,0.0003439354,0.0003267739,0.0006340031,0.001726713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004505666,"about_ca_system_score_gemma":0.0005723963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002673976,"about_ca_topic_score_gemma":0.003051831,"domain_scores_codex":[0.9998009,0.00001347692,0.00001695014,0.00004791344,0.00007223753,0.00004861481],"domain_scores_gemma":[0.9998769,0.000007149801,0.00002702141,0.00000839336,0.00003871746,0.00004176318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002806938,0.00002772722,0.0006925515,0.0002379554,0.00001432539,0.00009479729,0.00005183176,0.0001242008,0.9893196,0.0005621572,0.002755024,0.00583919],"study_design_scores_gemma":[0.00008266657,0.000419667,0.02502175,0.00007625311,0.00007840774,0.0004603834,0.0002895519,0.002477362,0.9259756,0.000472467,0.04461342,0.0000325657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9102325,0.0123468,0.02181141,0.001899378,0.00126312,0.0003096536,0.0356742,0.002730256,0.01373269],"genre_scores_gemma":[0.9536703,0.004125288,0.00734396,0.0006776505,0.0001179195,0.0001773731,0.01299235,0.0002227561,0.02067235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007248658,"threshold_uncertainty_score":0.0242492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0218161995333605,"score_gpt":0.3532570040639005,"score_spread":0.33144080453054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}