{"id":"W4407866806","doi":"10.1158/2326-6074.io2025-a060","title":"Abstract A060: Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Glioblastoma; Glioma; Stem cell; Cancer research; CCL5; Temozolomide; Medicine; Biology; T cell; Immunology; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004954152,0.0002765078,0.0002806931,0.0002339006,0.0003067903,0.00005560184,0.0006197298,0.0005110393,0.00009270938],"category_scores_gemma":[0.0001326338,0.0002571899,0.0001168553,0.0006978931,0.0006779522,0.0000235179,0.0004967168,0.000569043,0.00008401007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604082,"about_ca_system_score_gemma":0.0008887595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001007445,"about_ca_topic_score_gemma":0.00005669809,"domain_scores_codex":[0.9973039,0.0002961279,0.0003713224,0.0008331723,0.0003242005,0.0008712551],"domain_scores_gemma":[0.9981561,0.00008517937,0.0001609237,0.0007966639,0.0007178016,0.00008333732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001542375,0.0002007097,0.000600997,0.0001391184,0.0002098163,0.00004014247,0.0001307072,0.00001414986,0.9821813,0.00009102402,0.007538564,0.00731116],"study_design_scores_gemma":[0.001247747,0.0003365378,0.01052693,0.0002801844,0.00001749404,0.00001597075,0.0002991996,0.00003594509,0.9566391,0.0001896764,0.03017887,0.0002323583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724658,0.02147231,0.0001084326,0.0005841941,0.0003209598,0.0009083164,0.00006709812,0.00005459617,0.004018359],"genre_scores_gemma":[0.9956473,0.001326891,0.0001182934,0.0000599454,0.0001376576,0.0005381554,0.0001097697,0.00004491372,0.002017085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02554215,"threshold_uncertainty_score":0.999988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0218161995333605,"score_gpt":0.3532570040639005,"score_spread":0.33144080453054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}