{"id":"W4407869137","doi":"10.1016/j.jphyss.2025.100012","title":"Rebastinib inhibits FoxO1 activity and reduces dexamethasone-induced atrophy and its-related gene expression in cultured myotubes","year":2025,"lang":"en","type":"article","venue":"The Journal of Physiological Sciences","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Adaptable and Seamless Technology Transfer Program through Target-Driven R and D; Bio-oriented Technology Research Advancement Institution; Council for Science, Technology and Innovation; Princess Takamatsu Cancer Research Fund; National Agriculture and Food Research Organization; Shizuoka University; Swine Innovation Porc","keywords":"Myogenesis; Muscle atrophy; Downregulation and upregulation; Atrophy; FOXO1; C2C12; Skeletal muscle; Endocrinology; Internal medicine; Myocyte; Protein degradation; Ubiquitin; Biology; Chemistry; Transcription factor; Cell biology; Medicine; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006054155,0.0001066417,0.0001847996,0.00004218424,0.0002002997,0.0000143474,0.0002186811,0.0001242302,0.000005469022],"category_scores_gemma":[0.0003252853,0.0000537149,0.00004239755,0.0001969018,0.0003828279,0.0000173251,0.0001663735,0.0001808506,2.711979e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004313621,"about_ca_system_score_gemma":0.00004730431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007454108,"about_ca_topic_score_gemma":0.000004035978,"domain_scores_codex":[0.999034,0.0003277889,0.0001900923,0.0001948258,0.00009235569,0.0001609725],"domain_scores_gemma":[0.9996007,0.0000923928,0.0001496023,0.00006853206,0.00004485636,0.00004390323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002884984,0.00005043412,0.0002326583,0.000004562607,0.00001150805,5.356786e-7,0.00007334561,0.000120544,0.9977773,0.00004428135,0.00005973912,0.001336596],"study_design_scores_gemma":[0.0004515933,0.0008096703,0.0659031,0.00004300538,0.00001192242,0.000008477129,0.0002501888,0.00008893712,0.9293142,0.003019662,0.00001838429,0.00008086638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964967,0.002661051,0.00002124277,0.0005155948,0.00007176407,0.00008235362,0.000001016864,0.000002619574,0.0001475966],"genre_scores_gemma":[0.9984546,0.001173288,0.0001823467,0.0001297912,0.00004011124,0.000001781418,6.53992e-7,0.000001687003,0.00001569046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0684631,"threshold_uncertainty_score":0.219043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02294834760513759,"score_gpt":0.2985668853849914,"score_spread":0.2756185377798538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}