{"id":"W4407869314","doi":"10.1101/2025.02.21.639481","title":"Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Subtelomere; Gene silencing; Compartment (ship); Biology; Chromosome; Gene; Genetics; Computational biology; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007665712,0.0001345104,0.0001229164,0.0001488217,0.0001408585,0.0003407531,0.0001384953,0.0001939116,0.001063007],"category_scores_gemma":[0.0001336116,0.0001341426,0.0001232478,0.00007930296,0.0002237124,0.0001312979,0.0002642736,0.0003159561,0.0005068856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140713,"about_ca_system_score_gemma":0.0001796701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006741992,"about_ca_topic_score_gemma":0.001128554,"domain_scores_codex":[0.999931,0.00001023215,0.000006869681,0.00001851733,0.00001894619,0.00001435638],"domain_scores_gemma":[0.9998727,0.00002502441,0.00004192994,0.00001927164,0.00001140399,0.00002955028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004041912,0.000003187741,0.0002248847,0.00001230616,0.000001142488,0.00002689512,0.000009797018,0.00001856814,0.9991283,0.0001082719,0.0000189412,0.0004073821],"study_design_scores_gemma":[0.00001167716,0.00005658978,0.01938808,0.000007513407,0.000008062522,0.0002640341,0.0000360594,0.0007175537,0.9766105,0.0001673398,0.00272905,0.000003518321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945392,0.001431948,0.002307044,0.00009311971,0.00001623845,0.000007299475,0.0002605845,0.00008354699,0.001260937],"genre_scores_gemma":[0.9963958,0.0003049979,0.0009316325,0.00002803286,0.000004864621,0.00000795912,0.0005110514,0.00002853464,0.001787132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063007,"threshold_uncertainty_score":0.003556132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515496235449835,"score_gpt":0.2933220055263542,"score_spread":0.2681670431718559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}