{"id":"W4407869888","doi":"10.3390/microorganisms13030492","title":"Metabolic Reprogramming in Response to Freund’s Adjuvants: Insights from Serum Metabolomics","year":2025,"lang":"en","type":"article","venue":"Microorganisms","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Adjuvant; Freund's adjuvant; Metabolomics; Metabolite; Population; Immunology; Biology; Metabolism; Biochemistry; Chemistry; Medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004646766,0.0003478674,0.000662092,0.0005105531,0.0001823408,0.00005000815,0.0007112218,0.0004589476,0.0006483451],"category_scores_gemma":[0.0003294083,0.0003479134,0.0001132681,0.000915365,0.0001618148,0.0001190302,0.0004662911,0.0005740327,0.001699289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828904,"about_ca_system_score_gemma":0.0002416127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007315413,"about_ca_topic_score_gemma":0.0004616119,"domain_scores_codex":[0.9973596,0.0005649908,0.0006243703,0.0007874235,0.00004593826,0.0006177036],"domain_scores_gemma":[0.9984556,0.0003151112,0.0001109738,0.001000133,0.00008495266,0.00003323598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008223625,0.0001210085,0.001572823,0.000006453703,0.0002085239,0.00001826115,0.0019093,0.000008565278,0.9812455,0.0005659257,0.002228508,0.0112928],"study_design_scores_gemma":[0.001372364,0.00003409336,0.02607211,0.00005035141,0.00005461384,0.000004920759,0.0004823565,3.916769e-7,0.6235911,0.000623159,0.3474869,0.0002276617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517221,0.04193312,0.0005756938,0.001025595,0.003456756,0.0005033477,0.00007049862,0.0001589911,0.0005538972],"genre_scores_gemma":[0.9858826,0.0002029858,0.003068021,0.002618856,0.00004058476,0.00006628958,0.0000678534,0.00005375213,0.007999094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3576544,"threshold_uncertainty_score":0.9998973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006638098887165995,"score_gpt":0.2405463538200872,"score_spread":0.2339082549329212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}