{"id":"W4407869888","doi":"10.3390/microorganisms13030492","title":"Metabolic Reprogramming in Response to Freund’s Adjuvants: Insights from Serum Metabolomics","year":2025,"lang":"en","type":"article","venue":"Microorganisms","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Adjuvant; Freund's adjuvant; Metabolomics; Metabolite; Population; Immunology; Biology; Metabolism; Biochemistry; Chemistry; Medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002140681,0.0004506121,0.0003604436,0.0006072891,0.0001134796,0.0004120115,0.00009693693,0.0002767628,0.0003269693],"category_scores_gemma":[0.0001849548,0.0001148335,0.0003323707,0.0004438302,0.0001740355,0.0002488002,0.0002178095,0.000389773,0.0001366397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050094,"about_ca_system_score_gemma":0.0002712599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000703789,"about_ca_topic_score_gemma":0.001005615,"domain_scores_codex":[0.9998888,0.00001783415,0.000006116799,0.00003047139,0.00002823313,0.0000285393],"domain_scores_gemma":[0.9998906,0.00001296988,0.00004379272,0.000008112118,0.00002305877,0.00002153396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003394973,0.00002098811,0.003269205,0.00004875927,0.00001873577,0.00003969503,0.00002092603,0.0001068901,0.9924286,0.00004686845,0.00003110352,0.003628773],"study_design_scores_gemma":[0.00002571604,0.0009169661,0.216353,0.00003965279,0.0001330552,0.0004751461,0.0002179163,0.005514566,0.7718681,0.0006205882,0.003784154,0.0000511828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856719,0.004131524,0.00756635,0.000134767,0.00003084416,0.00003248125,0.001704335,0.00006335839,0.0006643884],"genre_scores_gemma":[0.9837121,0.003678272,0.00910987,0.0001908615,0.00002040569,0.00005500334,0.002028348,0.00002934474,0.001175812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000703789,"threshold_uncertainty_score":0.001487434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006638098887165995,"score_gpt":0.2405463538200872,"score_spread":0.2339082549329212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}