{"id":"W4407877968","doi":"10.1053/j.gastro.2025.01.247","title":"Epstein-Barr Virus Exposure Precedes Crohn's Disease Development","year":2025,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Walter Reed Army Institute of Research; Naval Medical Research Center; Department of Medicine, University of Toronto; Brigham and Women's Hospital; Kenneth Rainin Foundation; University of Toronto; Broad Institute; Icahn School of Medicine at Mount Sinai; Harvard University; Margaret M. and Albert B. Alkek Department of Medicine; University of Nevada, Reno; U.S. Food and Drug Administration; Henry M. Jackson Foundation; Harvard Medical School; Williams","keywords":"Crohn's disease; Virology; Virus; Epstein–Barr virus; Disease; Medicine; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818879,0.0001945364,0.0004551124,0.001236298,0.0004500152,0.001294752,0.0002343447,0.0007876194,0.005131435],"category_scores_gemma":[0.002488972,0.0003934531,0.0002830839,0.0005070572,0.0003860998,0.0006113718,0.00047116,0.0009875726,0.0007790649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003953373,"about_ca_system_score_gemma":0.0004591634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001889287,"about_ca_topic_score_gemma":0.001932422,"domain_scores_codex":[0.9995984,0.0001050085,0.00002219715,0.00007372986,0.00006952759,0.000131166],"domain_scores_gemma":[0.9973725,0.0009978104,0.0005950065,0.0001606082,0.0001841193,0.0006898869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005876279,0.0002760266,0.9111017,0.0001911087,0.00007731865,0.005396011,0.0004867259,0.0001271007,0.05624432,0.001062297,0.0006787589,0.01848247],"study_design_scores_gemma":[0.00001358019,0.0003102013,0.9906362,0.00004884503,0.00002314138,0.003153615,0.0002529707,0.0000776646,0.003565914,0.0001926007,0.001716995,0.000008294516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900164,0.003765719,0.0004123274,0.0001785923,0.0001033147,0.00001661858,0.000281609,0.00004686234,0.005178558],"genre_scores_gemma":[0.9983703,0.0004517307,0.0001176604,0.00002269765,0.00002672122,0.000004010342,0.0001259218,0.000006538395,0.0008742409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005131435,"threshold_uncertainty_score":0.01716632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005232464184994438,"score_gpt":0.2244417263164458,"score_spread":0.2192092621314513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}