{"id":"W4407910138","doi":"10.3390/ijms26052005","title":"Insight into crRNA Processing in Streptococcus mutans P42S and Application of SmutCas9 in Genome Editing","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Streptococcus mutans; Trans-activating crRNA; Genome editing; Biology; Computational biology; Genome; Genetics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211,0.0002789576,0.0002013003,0.0001294025,0.0001446221,0.0003543097,0.0001898644,0.0003795014,0.0005270874],"category_scores_gemma":[0.0001372462,0.0001035775,0.0002167242,0.0001180798,0.0001963629,0.0002101945,0.0001581938,0.0004651754,0.0002286021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520358,"about_ca_system_score_gemma":0.0001976865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006735165,"about_ca_topic_score_gemma":0.0006633116,"domain_scores_codex":[0.9999036,0.00001503654,0.000007446893,0.00002178509,0.00003555978,0.00001673601],"domain_scores_gemma":[0.9999576,0.00001244697,0.00001004814,0.000005900854,0.000004843774,0.000009247859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002864538,0.00001017662,0.0001310395,0.00003818493,0.000001609659,0.0001145151,0.00001465701,0.0003089588,0.9969249,0.0002990741,0.0000139527,0.002114193],"study_design_scores_gemma":[0.000003057769,0.0001052081,0.001401982,0.000006986493,0.000004424719,0.00039866,0.00003426988,0.003398964,0.9915753,0.0002214277,0.002843404,0.000006439095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740523,0.00294112,0.01824747,0.0002461332,0.00002977725,0.00003940687,0.0002436198,0.0001912806,0.004008881],"genre_scores_gemma":[0.9864987,0.001237844,0.009827219,0.00003807021,0.000004883929,0.00001453449,0.0001828866,0.00002374362,0.002172115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006735165,"threshold_uncertainty_score":0.001828671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004276712657993702,"score_gpt":0.3132712250185331,"score_spread":0.3089945123605394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}